Contribution of Airway Resistance to Airway Pressure during Mechanical Ventilation : an Experimental Study
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概要
- 論文の詳細を見る
Although airway resistance (R) is an important parameter of the pulmonary condition, its determination during mechanical ventilation is not easy. Most physicians estimate R from peak airway pressure during mechanical ventilation. We assessed the relationship between R and peak airway pressure by a computer simulation. The time course of airway pressure (Ptr) during mechanical ventilation was calculated from the airway pressure at end-inspiration and respiratory flow, allowing for the buffering effect of the dead space. The parameters for computer simulation were obtained from 5 paralyzed and mechanically ventilated dogs. The predicted Ptr curve was a function of airway resistance. Since R was not directly determined by the animal experiments, we determined R by using the Ptr curve most closely approximating the original Ptr curve as the true R. The R-peak tracheal pressure relationship predicted by computer simulation showed that the peak airway pressure increased almost linearly with increases in R. However, in computer simulation, when R was increased 10-fold from the value at airway relaxation, the peak airway pressure increased only 6-fold from the corresponding value. We conclude that peak airway pressure is a relatively insensitive parameter for the estimation of airway constriction during mechanical ventilation.
- 東海大学の論文
著者
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KOBAYASHI Ichiro
Department of Life Science,Tokyo Institute of Technology
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ISHII Makoto
Departments of Internal Medicine 2, Tokai University School of Medicine
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KONDO Tetsuri
Department of Medicine, Tokai University Oiso Hospital
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HAYAMA Naoki
Department of Medicine, Tokai University School of Medicine
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Ishii Makoto
Department Of Medicine Tokai University School Of Medicine
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Kobayashi I
Department Of Medicine Tokai University Oiso Hospital
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Iwasaki M
Department Of General Thoracic Surgery Tokai University School Of Medicine
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Iwasaki Masayuki
Corporate Research And Development Laboratories Pioneer Electronic Corp.
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Kobayashi Intetsu
Mitsubishi Kagaku B.c.l.inc.
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Ohta Y
Division Of Specialized Clinical Science (dermatology) Tokai University School Of Medicine
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Hayama Naoki
Department Of Medicine Tokai University School Of Medicine
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Kondo T
Department Of Medicine Tokai University Oiso Hospital
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Kondo Tetsuri
Department Of Medicine Tokai University School Of Medicine
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Kondo Tetsuri
Department Of Internal Medicine Tokai University School Of Medicine
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TAZAKI Gen
Department of Medicine, Tokai University School of Medicine
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OHTA Yasuyo
Department of Medicine, Tokai University School of Medicine
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ONOUE Yasuo
Onoue Clinic
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Tazaki Gen
Department Of Respiratory Medicine Tokai University Hachioji Hospital
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Kondo T
Department Of Respiratory Medicine Tokai University Hachioji Hospital
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Kondo T
Department Of Medicine Tokai University School Of Medicine
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Ishii Makoto
Department Of Environmental Chemistry And Engineering Tokyo Institute Of Technology
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Ohta Yasuyo
Department Of Medicine Tokai University School Of Medicine
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Kobayashi Ichiro
Department Of Life Science Tokyo Institute Of Technology
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Ishii Makoto
Department of Clinical Pharmacokinetics, Hoshi University
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