Studies on Gas Exchange and Acid-base Balance in the Tissue by Means of the Subcutaneous Liquid Pocket with Fluorocarbon Emulsion
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概要
- 論文の詳細を見る
A subcutaneous liquid pocket with fluorocarbon emulsion has been used as a new means to assess acid-base balance and gas exchange in the tissue. The pocket contents of rats under ambient air breathing showed a pO_2 of 45.8±3.3 Torr, pCO_2 of 49.0±1.3 Torr, pH of 7.374±0.052 and HCO^-_3 of 17.1±2.2 mEq/L. Changes in the above parameters were studied under hypoxic, hypercapneic and asphyxic environments and comparied in part with those in arterial blood. Respiratory alkalosis under hypoxia and respiratory acidosis with some improvement in oxygenation in the tissues were observed. Acetazolamide given intraperitoneally under asphyxic conditions not only induced metabolic acidosis, but also caused a deterioration in tissue hypoxia, which may limit the therapeutic use of acetazolamide in respiratory acidosis.
- 東海大学の論文
著者
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Ohta Yasuyo
Department Of Medicine Tokai University School Of Medicine
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Kodaka Yasuko
Department Of Physiology School Of Medicine Tokai University
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