Regulation of Intracranial Pressure in the Rat with Chronic Moderate Hypercapnia
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概要
- 論文の詳細を見る
Study objectives: In this animal study we investigated whether CO_2-induced intracranial hypertension was sustained in chronic hypercapnia. Design: We kept five rats in a 10% CO_2-air mixture (PaCO_2 73.4±6.2 Torr, mean±1SD) for 22 weeks, and then measured the rats' intracranial pressure while breathing the 10% CO_2-air mixture or the room air. Results: The intracranial pressures recorded during chronic hypercapnia in systole and diastole were 7.0±1.9 and 5.4±1.6 mm Hg, respectively. When the rats were acutely exposed to the room air (PaCO_2, 51.9±10.2 Torr), the intracranial pressures in systole and diastole were 6.1±1.4 and 5.0±0.8 mm Hg, respectively, were not significantly different from those during hypercapnia (P>0.05, paired t-test). Conclusions: The intracranial pressure in rats with chronic moderate hypercapnia was not significantly different from normocapnic rats, and this change was associated with a blunting of intracranial pressure autoregulation.
- 東海大学の論文
著者
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KONDO Tetsuri
Department of Medicine, Tokai University Oiso Hospital
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Ohta Y
Division Of Specialized Clinical Science (dermatology) Tokai University School Of Medicine
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Kondo T
Department Of Medicine Tokai University Oiso Hospital
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Kondo Tetsuri
Department Of Medicine Tokai University School Of Medicine
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Kondo Tetsuri
Department Of Internal Medicine Tokai University School Of Medicine
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OHTA Yasuyo
Department of Medicine, Tokai University School of Medicine
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KUMAGAI Miho
Department of Medicine, Tokai University School of Medicine
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ONOUE Yasuo
Onoue Clinic
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TAKEI Futoshi
Department of Neurosurgery Tokai University School of Medicine
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KANAYAMA Ichiro
Department of Internal Medicine Tokai University School of Medicine
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Kumagai M
Kyoundo Hiratsuka Hospital:tokai University Hospital
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Kondo T
Department Of Respiratory Medicine Tokai University Hachioji Hospital
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Kondo T
Department Of Medicine Tokai University School Of Medicine
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Ohta Yasuyo
Department Of Medicine Tokai University School Of Medicine
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