The Threshold of the Intermittent Hypoxic Exposure Period to Elicit Polycythemia in Rats
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概要
- 論文の詳細を見る
It is not yet clear whether there is an intermittent hypoxia (IHx) threshold to elicit polycythemia and blood pressure elevation, and whether blood hemoglobin concentration ([Hb]) increases with an increase in the hypoxic exposure period. We have previously shown that repetitive exposure to 10% O_2 for 60 min/day for up to 5 weeks does not produce polycythemia. In the present study, we evaluated the effect of IHx of 10% O_2, 120 min/day for 1, 2, 3 and 4 weeks on [Hb], arterial blood pressure, heart rate and arterial blood gases in the rat. IHx of 10% O_2, 120 min/day induced polycythemia at 1 week and produced a time-dependent increase in [Hb] from 0 week to 4 weeks. Arterial blood pressure significantly increased during IHx exposure for 4 weeks probably due to a combination of an increased sympathetic activity as well as increased blood viscosity. The IHx threshold for polycythemia might exist between 60 min/day and 120 min/day in this level of hypoxia.
- 東海大学の論文
著者
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ISHII Makoto
Departments of Internal Medicine 2, Tokai University School of Medicine
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URANO Tetsuya
Department of Internal Medicine, Tokai University School of Medicine
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Ishii Makoto
Department Of Medicine Tokai University School Of Medicine
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Urano Tetsuya
Department Of Internal Medicine Tokai University School Of Medicine
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Urano T
Department Of Medicine Tokai University School Of Medicine
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Urano Tetsuya
Department Of Medicine Tokai University School Of Medicine
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Kobayashi I
Department Of Medicine Tokai University Oiso Hospital
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Kuwahira Ichiro
Department Of Medicine School Of Medicine Tokai University
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Kuwahira Ichiro
Department Of Internal Medicine Tokai University School Of Medicine
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Iwasaki M
Department Of General Thoracic Surgery Tokai University School Of Medicine
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Iwasaki Masayuki
Corporate Research And Development Laboratories Pioneer Electronic Corp.
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Kobayashi Intetsu
Mitsubishi Kagaku B.c.l.inc.
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IWAMOTO Tokuzen
Department of Medicine, Tokai University School of Medicine
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KAMIYA Uguri
Department of Medicine, Tokai University School of Medicine
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Iwamoto Tokuzen
Department Of Medicine Tokai University Tokyo Hospital:department Of Medicine Tokai University Schoo
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Kamiya Uguri
Department Of Medicine Ikegami General Hospital:department Of Medicine Tokai University School Of Me
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Ishii Makoto
Department Of Environmental Chemistry And Engineering Tokyo Institute Of Technology
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Ishii Makoto
Department of Clinical Pharmacokinetics, Hoshi University
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