Long-term Sustained Mixed Chimerism after Allogeneic Stem Cell Transplantation in a Patient with Severe Aplastic Anemia
スポンサーリンク
概要
- 論文の詳細を見る
Mixed chimerism in a post-transplant patient with severe aplastic anemia (SAA) is generally considered to be a status preceding donor-cell rejection and bone marrow failure. Here, we report on a rare, prolonged mixed chimerism in a patient with SAA who showed a full recovery in hematological and immunological status after transplantation. The analysis in this patient showed about 20% and 80% recipient-type cells of total blood cells and T cells, respectively, at two years post-transplantation, and 14% and 25% of total blood cells and T cells, respectively, at four years post-transplantation. This report describes the most comprehensive case study known to date.
著者
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OGAWA Seishi
Department of Cell Therapy & Transplantation Medicine University of Tokyo Hospital
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CHIBA Shigeru
Department of Cell Therapy & Transplantation Medicine University of Tokyo Hospital
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Saito Akiko
Department Of Applied Biological Chemistry The University Of Tokyo
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Hirai Hisamaru
Department Of Cell Therapy And Transplantation University Of Tokyo
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Kanda Yoshinobu
Department Of Cell Therapy And Transplantation Medicine University Of Tokyo
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Kurokawa Mineo
Department of Hematology & Oncology, The University of Tokyo
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Hirai Hisamaru
Department of Hematology/Oncology, Graduate School of Medicine and Department of Cell Therapy/Transplantation Medicine, University of Tokyo Hospital, University of Tokyo
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Kurokawa Mineo
Department of Hematology/Oncology, Graduate School of Medicine and Department of Cell Therapy/Transplantation Medicine, University of Tokyo Hospital, University of Tokyo
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Saito Akiko
Department of Hematology/Oncology, Graduate School of Medicine and Department of Cell Therapy/Transplantation Medicine, University of Tokyo Hospital, University of Tokyo
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Chiba Shigeru
Department of Hematology/Oncology, Graduate School of Medicine and Department of Cell Therapy/Transplantation Medicine, University of Tokyo Hospital, University of Tokyo
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Kanda Yoshinobu
Department of Hematology/Oncology, Graduate School of Medicine and Department of Cell Therapy/Transplantation Medicine, University of Tokyo Hospital, University of Tokyo
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