A Case of Myeloid Sarcoma with Correlation to JAK2V617F Mutation, Complicated by Myelofibrosis and Secondary Acute Myeloid Leukemia
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概要
- 論文の詳細を見る
The activating mutation of JAK2, V617F, has been found as a frequent mutation in myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocytosis (ET), and primary myelofibrosis (PMF). This mutation is observed not only in MPNs, but also in chronic myelomonocytic leukemia, myelodysplastic syndrome and acute myeloid leukemia (AML). We report a case of myeloid sarcoma and myelofibrosis, followed by secondary AML, with detection of homozygous JAK2 V617F mutation. This report describes the first case of myeloid sarcoma with JAK2 V617F mutation and implication of its progression to AML.
著者
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Yoshiki Yumiko
Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku University
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Ota Satoshi
Department Of Breast And Endocrine Surgery Faculty Of Medicine The University Of Tokyo
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Asai Takashi
Department Of Anesthesiology Kansai Medical University
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Takahashi Tsuyoshi
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicine
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Hangaishi Akira
Department Of Hematology And Oncology Graduate School Of Medicine The University Of Tokyo
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Imai Yoichi
Department Of Hematology And Oncology Graduate School Of Medicine The University Of Tokyo
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Kurokawa Mineo
Department of Hematology & Oncology, The University of Tokyo
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Ichikawa Motoshi
Department of Hematology & Oncology, The University of Tokyo
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Kurokawa Mineo
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
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Ota Satoshi
Department of Pathology, University of Tokyo Hospital, Japan
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Ichikawa Motoshi
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
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