A Comparative Analysis of Meropenem and Doripenem in Febrile Patients with Hematologic Malignancies: a Single-Center Retrospective Study
スポンサーリンク
概要
- 論文の詳細を見る
Many patients with hematologic malignancies show immunosuppression and/or neutropenia, and are at a high risk of developing a serious infection that would require empiric therapy with broad-spectrum antibiotics. However, a thorough comparison of the efficacies of different carbapenems has not been carried out. To compare the efficacies of meropenem (MEPM) and doripenem (DRPM) in febrile patients with hematologic neoplasms, we retrospectively reviewed data of 149 consecutive febrile patients with acute myeloid leukemia, acute lymphoblastic leukemia, or myelodysplastic syndrome (MDS) who were treated empirically with MEPM or DRPM. The duration from the start of carbapenem administration to decline of fever was not significantly different between the MEPM and DRPM groups (median, 3 versus 4 days; P = 0.79). Multivariate analysis showed that a diagnosis of MDS and the use of liposomal amphotericin-B or voriconazole are statistically significant risk factors for sustained fever. In conclusion, MEPM and DRPM showed similar efficacies in febrile patients with acute leukemia and MDS.
著者
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Nannya Yasuhito
Department Of Hematology And Oncology Graduate School Of Medicine University Of Tokyo
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Nannya Yasuhito
Regeneration Medicine For Hematopoiesis Graduate School Of Medicine The University Of Tokyo
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Ichikawa Motoshi
Department Of Hematology And Oncology Graduate School Of Medicine University Of Tokyo
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Toya Takashi
Department Of Materials Science And Chemical Engineering Faculty Of Engineering Shizuoka University
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Kurokawa Mineo
Department Of Hematology And Oncology Graduate School Of Medicine The University Of Tokyo
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Narukawa Kensuke
Department of Hematology & Oncology, The University of Tokyo
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Ichikawa Motoshi
Department Of Hematology And Oncology Graduate School Of Medicine The University Of Tokyo
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Narukawa Kensuke
Department of Hematology & Oncology, The University of Tokyo
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Nannya Yasuhito
Department of Hematology & Oncology, The University of Tokyo
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Kurokawa Mineo
Department of Hematology & Oncology, The University of Tokyo
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Ichikawa Motoshi
Department of Hematology & Oncology, The University of Tokyo
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Toya Takashi
Department of Hematology & Oncology, The University of Tokyo
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