STUDIES OF REPEATED ADMINISTRATION OF FK-506 ON MYOCARDIAL METABOLISM IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
The effect of a 14-day administration of FK-506 at 1 or 3 mg/kg on plasma lipids and myocardial energy and glucose metabolism in rats was investigated. FK-506 increased the level of blood glucose in rats when given daily at an oral dosage of 3 mg/kg for 14 days. The plasma level of total cholesterol was significantly increased by FK-506 at either 1 or 3 mg/kg, whereas that of triglyceride was not changed. There was no significant difference in energy charge potential and the lactate/pyruvate ratio of the myocardial tissue between FK-506-and solvent-treated groups. Because FK-506 administration for 14 consecutive days did not disturb myocardial energy and glucose metabolism, its cardiotoxic side effects were not recognized in the present experimental toxicological evaluation of rats.
- 日本トキシコロジー学会の論文
著者
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ICHIHARA Kazuo
Department of Pharmacology, Asahikawa Medical College
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Yamamoto Atsuko
Department of Legal Medicine, The Tokushima University School of Medicine
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SATOH Kumi
Department of Pharmacology, Hokkaido College of Pharmacy
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Satoh Kumi
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Satoh Kumi
Department Of Pharmacology Hokkaido Institute Of Pharmaceutical Sciences:department Of Pharmacology
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YOSHIDA Akimasa
Department of Neurosurgery, Kumamoto Rosai Hospital
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HOSHI Katsuji
Department of Clinical Pharmacology, Hokkaido College of Pharmacy
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Hoshi K
Dept. Of Phramacol. Hokkaido College Of Pharmacy
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Hoshi Katsuji
Department Of Clinical Pharmacology Hokkaido College Of Pharmacy
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Satoh Kiyotaka
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Ichihara K
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Ichihara Kazuo
Department Of Clinical Pharmacology Asahikawa Medical College
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Yoshida A
Department Of Pharmacology Hokkaido College Of Pharmacy
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Yoshida Akimasa
Department Of Electrical Electronics And Computer Engineering Waseda University
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Yamamoto A
Department Of Pharmacology Hokkaido College Of Pharmacy
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Yamamoto Atsuko
Department Of Dermatology Osaka City University Medical School
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Yamamoto Atsuko
Department Of Chemical Engineering Osaka Prefecture University
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