Effects of Minoxidil on Ischemia-Induced Mechanical and Metabolic Dysfunction in Dog Myocardium
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概要
- 論文の詳細を見る
Effects of minoxidil on ischemia-induced myocardial mechanical and metabolic dysfunction were examined in anesthetized open-chest dogs. A regional portion of the left ventricle was made ischemic for 20 min by ligating the left anterior descending coronary artery, and then reperfused for 120 min. Dimethylsulfoxide or minoxidil (0.3, or 1.0 mg/kg) was injected intravenously 10 min before ligation. Ischemia decreased regional myocardial contraction, and reperfusion recovered it but incompletely. Myocardial metabolic derangement was observed during ischemia, such as decreases in the myocardial levels of ATP and creatine phosphate. These metabolic changes caused by ischemia were restored by reperfusion. Minoxidil injection at 0.3 and 1.0 mg/kg significantly decreased blood pressures but increased coronary flow. Pretreatment with minoxidil significantly enhanced the recovery of myocardial contraction during reperfusion after ischemia. The levels of ATP and creatine phosphate in the ischemic myocardium were significantly preserved by minoxidil at 0.3 mg/kg. No significant effect of minoxidil on the metabolism was observed in the 120 min reperfused myocardium. In conclusion, minoxidil improved the mechanical dysfunction in the reperfused heart and the drug at low dose preserved high-energy phosphates during ischemia.
- 社団法人 日本薬理学会の論文
- 2002-10-01
著者
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ICHIHARA Kazuo
Department of Pharmacology, Asahikawa Medical College
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Yamamoto Atsuko
Department of Legal Medicine, The Tokushima University School of Medicine
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SATOH Kumi
Department of Pharmacology, Hokkaido College of Pharmacy
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Satoh Kumi
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Satoh Kumi
Department Of Pharmacology Hokkaido Institute Of Pharmaceutical Sciences:department Of Pharmacology
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Satoh Kiyotaka
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Ichihara K
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Ichihara Kazuo
Department Of Clinical Pharmacology Asahikawa Medical College
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KANETA Shigeru
Department of Pharmacotherapeutics, Hokkaido College of Pharmacy
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Kaneta Shigeru
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Kaneta Shigeru
Department Of Pharmacotherapeutics Hokkaido College Of Pharmacy
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KANO Seiichiro
Division of Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy
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ICHINOSAWA Kenichi
Department of Pharmacology, Hokkaido College of Pharmacy
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KANO Seiichiro
Department of Pharmacology, Hokkaido College of Pharmacy
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Yamamoto A
Department Of Pharmacology Hokkaido College Of Pharmacy
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Yamamoto Atsuko
Department Of Dermatology Osaka City University Medical School
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Yamamoto Atsuko
Department Of Chemical Engineering Osaka Prefecture University
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Ichinosawa Kenichi
Department Of Pharmacology Hokkaido College Of Pharmacy
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Kano Seiichiro
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Kaneta Shigeru
Department of Pharmacology, Hokkaido College of Pharmacy
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