Protective Effect of Amiloride Against Reperfusion Damage as Evidenced by Inhibition of Accumulation of Free Fatty Acids in Working Rat Hearts
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概要
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To examine whether amiloride protects against ischemia-induced or reperfusion-induced damage to the heart, mechanical and metabolic studies were performed in the isolated, working rat heart. Ischemia decreased both mechanical function and the tissue levels of high-energy phosphates and increased the tissue levels of free fatty acids (FFAs). Reperfusion restored the levels of high-energy phosphates but further increased FFA accumulation. For this reason, accumulation of FFAs was used as an indicator of both ischemia-induced and reperfusion-induced damage. Drugs were added to the perfusion solution 5 min before ischemia until the end of ischemia (pre) or until 10 min after reperfusion (pre+post). Diltiazem (1 or 5μmol/L pre) decreased the mechanical function of the non-ischemic heart and attenuated both ischemia-induced and reperfusion-induced accumulation of FFAs. Amiloride (50μmol/L pre) did not affect the mechanical function of the non-ischemic heart or attenuate ischemia-induced or reperfusion-induced FFA accumulation effectively. However, amiloride (50μmol/L pre+post) did markedly attenuate the reperfusion-induced accumulation of FFAs. In conclusion, diltiazem attenuates both ischemia-induced and reperfusion-induced myocardial damage, probably through its energy-sparing effect as a result of a decrease in mechanical function before ischemia. In contrast, amiloride attenuates only the reperfusion-induced myocardial damage through mechanisms other than the energy-sparing effect.
- 社団法人日本循環器学会の論文
- 1997-11-20
著者
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Nasa Yoshihisa
Department Of Molecular And Cellular Pharmacology Tokyo University Of Pharmacy And Life Science
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Nasa Yoshihisa
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Hoque A.n.ehsanul
Department Of Pharmacology Asahikawa Medicak College
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ICHIHARA Kazuo
Department of Pharmacology, Asahikawa Medical College
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Hoque A.
Department of Pharmacology and Toxicology, University of Western Ontario
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Ichihara Kazuo
Department Of Pharmacology Hokkaido College Of Pharmacy
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Ichihara Kazuo
Department Of Clinical Pharmacology Asahikawa Medical College
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Hashizume Hiroko
Department Of Pharmacology Asahikawa Medical College
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Abiko Yasushi
Department Of Pharmacology Asahika Wa Medical College
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