FUNCTIONAL AND METABOLIC RESPONSES TO ISCHEMIA IN THE PERFUSED HEART ISOLATED FROM NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS
スポンサーリンク
概要
- 論文の詳細を見る
The difference between normotensive rats (WKY) and spontaneously hypertensive rats (SHR) in functional and metabolic responses to ischemia was studied. Systolic arterial blood pressure of SHR (171.2 ± 2.9 mmHg) was significantly higher than that of WKY (135.3 ± 1.2 mmHg), and the left ventricular mass of SHR was larger than that of WKY. Hearts isolated from either WKY or SHR were perfused by the working heart technique. Ischemia was induced by lowering the afterload pressure of the working heart. Ischemia produced cardiac arrest, and decreased the tissue levels of adenosine triphosphate and creatine phosphate in both WKY and SHR. Recovery of mechanical function of the heart during reperfusion following ischemia in SHR was better than that in WKY, while recovery of the high-energy phosphates level in SHR was less prominent than in WKY. It is postulated that hypertension has a deleterious effect on myocardial energy metabolism in ischemic heart, even when cardiac mechanical function is maintained.
- 社団法人日本循環器学会の論文
- 1986-07-20
著者
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HANEDA TAKASHI
First Department of Internal Medicine, Asahikawa Medical College, Hokkaido, Japan
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Haneda T
First Department Of Internal Medicine Asahikawa Medical College
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Haneda T
Nemuro Municipal Hospital
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Haneda Takashi
First Department Of Internal Medicine Asahikawa Medical College
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Hirayama Tomoya
旭川医科大学 1内
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ICHIHARA Kazuo
Department of Pharmacology, Asahikawa Medical College
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ABIKO Yasushi
Department of Pharmacology, Asahikawa Medical College
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ONODERA Sokichi
Ministry of Science, Education and Culture of Japan
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Onodera Sokichi
First Department Of Internal Medicine Asahikawa Medical College Nishikagura
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Abiko Yasushi
Department Of Pharmacology Asahikawa Medical College
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Abiko Y
Department Of Pharmacology Asahikawa Medical College
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Ichihara K
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Ichihara Kazuo
Department Of Clinical Pharmacology Asahikawa Medical College
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Onodera Sokichi
Ministry Of Science Education And Culture Of Japan
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Haneda Takashi
1st Department Of Internal Medicine Asahikawa Medical College
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Haneda Takashi
The First Department Of Internal Medicine Asahikawa Medical College
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Abiko Yasushi
Department Of Pharmacology
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