HMG-CoA Reductase Inhibitors Do Not Improve Glucose Intolerance in Spontaneously Diabetic Goto-Kakizaki Rats(Pharmacology)
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概要
- 論文の詳細を見る
We examined whether 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) improve glucose intolerance in spontaneously diabetic Goto-Kakizaki (GK) rats or not. The fasting blood glucose, plasma insulin, and serum cholesterol levels were significantly higher in GK rats than those in age-matched Wistar rats. All rats were given orally once a day 0.5% carboxymethylcellulose, pravastatin 8mg/kg, simvastatin 8mg/kg, or atorvastatin 8mg/kg. An oral glucose tolerance test (OGTT) was performed before and 3, 6 and 12 weeks after statin treatments. The hyperglycemic response to OGTT in GK rats significantly exceeded that in Wistar rats. The plasma insulin level in GK rats increased with age until 14-week-old (treated for 6 weeks), and then decreased. Glucose intake significantly increased the plasma insulin in almost all rats. The increment of plasma insulin due to OGTT in GK rats appeared to be less than that in Wistar rats, because the basal level was already high in GK rats. Pravastatin, simvastatin, and atorvastatin did not modify changes in blood glucose and plasma insulin induced by glucose intake. In conclusion, long-term treatments of GK rats with statins did not improve glucose intolerance observed during OGTT.
- 公益社団法人日本薬学会の論文
- 2005-11-01
著者
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KANDA Makoto
Department of Architecture and Architectural Engineering, College of Industrial Technology, Nihon Un
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KASAI TOSHINORI
Department of Urology and Pathology, Tokushima Red Cross Hospital
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ICHIHARA Kazuo
Department of Pharmacology, Asahikawa Medical College
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SATOH Kumi
Department of Pharmacology, Hokkaido College of Pharmacy
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Satoh Kumi
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Satoh Kumi
Department Of Pharmacology Hokkaido Institute Of Pharmaceutical Sciences:department Of Pharmacology
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Kanda Makoto
Department Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Satoh Kiyotaka
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Ichihara K
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Ichihara Kazuo
Department Of Clinical Pharmacology Asahikawa Medical College
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TAKAGURI Akira
Division of Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy
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Sun Fan
Department Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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KEIMATSU Natsue
Department of Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy
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TAKAGURI Akira
Department of Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy
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Takaguri Akira
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Kasai Toshinori
Department Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Kanda Makoto
Department Of Architecture And Architectural Engineering College Of Industrial Technology Nihon Univ
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Keimatsu Natsue
Department Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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