Myocardial ischemia stimulates catecholamine synthesis and catabolism in the dog adrenal medulla.
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概要
- 論文の詳細を見る
The effects of regional ischemia of the myocardium upon metabolism and catabolism of catecholamines were studied in the dog adrenal medulla. Regional ischemia was induced by ligating a small branch of the left anterior descending coronary artery for 1 or 24 hours. Sham-operated controls were run in parallel. Coronary ligation for 24 hours resulted in a decrease in the level of epinephrine and an increase in the level of dopamine in the adrenal medulla, and also resulted in an increase in the activities of the phenylethanolamine-N-methyltransferase (PNMT), monoamine oxidase, and catechol-O-methyltransferase. The results after coronary ligation for 1 hour were essentially the same as those after coronary ligation for 24 hours, except that the activity of PNMT decreased. These results suggest that both synthesis and catabolism of catecholamines in the adrenal medulla are accelerated during coronary ligation for a period of 1 to 24 hours.
- International Heart Journal刊行会の論文
著者
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Ichihara Kazuo
Department Of Clinical Pharmacology Asahikawa Medical College
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Sakai Kenji
Department Of Applied Chemistry Faculty Of Engineering Oita University
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Abiko Yasushi
Department Of Pharmacology
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PARVEZ Hasan
Neuropharmacology Unit, University of Paris XI
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PARVEZ Simone
Neuropharmacology Unit, University of Paris XI
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NAGATSU Toshiharu
First Department of Biochemistry, Nagoya University School of Medicine
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