Simvastatin and Atorvastatin Enhance Hypotensive Effect of Diltiazem in Rats
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概要
- 論文の詳細を見る
Effect of the 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) reductase inhibitors, simvastatin and atorvastatin, on diltiazem-induced hypotension were examined in anaesthetized rats and compared to that of pravastatin. Vehicle, 2 mg/kg/day simvastatin, 2 mg/kg/day atorvastatin, or 4 mg/kg/day pravastatin was administered orally for 4 days. Diltiazem at 3 mg/kg was given orally 2 hours after the final administration of the inhibitors. Arterial blood pressure was measured via a cannula introduced into the left carotid artery, and heart rate was counted from the pulse pressure. In all groups, diltiazem significantly decreased the mean arterial blood pressure without any changes in heart rate. Pretreatment with simvastatin and atorvastatin significantly enhanced the hypotensive effect of diltiazem, while that with pravastatin did not. Heart rate was not modified by pretreatment with the inhibitors. The results indicate that concomitant use of diltiazem with simvastatin or atorvastatin enhances diltiazem-induced hypotension, probably by competitive inhibition of diltiazem metabolism with simvastatin and atorvastatin metabolisms.
- 公益社団法人日本薬学会の論文
- 2001-10-01
著者
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ICHIHARA Kazuo
Department of Pharmacology, Asahikawa Medical College
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Yamamoto Atsuko
Department of Legal Medicine, The Tokushima University School of Medicine
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SATOH Kumi
Department of Pharmacology, Hokkaido College of Pharmacy
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Satoh Kumi
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Satoh Kumi
Department Of Pharmacology Hokkaido Institute Of Pharmaceutical Sciences:department Of Pharmacology
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Satoh Kiyotaka
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Ichihara K
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Ichihara Kazuo
Department Of Clinical Pharmacology Asahikawa Medical College
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Marumo Hiroshi
Department Of Pharmacology Hokkaido College Of Pharmacy
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KANETA Shigeru
Department of Pharmacotherapeutics, Hokkaido College of Pharmacy
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Kaneta Shigeru
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Kaneta Shigeru
Department Of Pharmacotherapeutics Hokkaido College Of Pharmacy
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KANO Seiichiro
Division of Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy
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Yamamoto A
Department Of Pharmacology Hokkaido College Of Pharmacy
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Yamamoto Atsuko
Department Of Dermatology Osaka City University Medical School
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Yamamoto Atsuko
Department Of Chemical Engineering Osaka Prefecture University
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Kano Seiichiro
Division Of Pharmacology Hokkaido Pharmaceutical University School Of Pharmacy
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Kaneta Shigeru
Department of Pharmacology, Hokkaido College of Pharmacy
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