Cyclical Changes in High-Energy Phosphates During the Cardiac Cycle by Pacing-Gated ^<31>P Nuclear Magnetic Resonance
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概要
- 論文の詳細を見る
Whether cyclical changes in energy-related phosphate metabolites arise during a cardiac cycle in isolated rat hearts and are affected by differences in myosin isozyme composition was determined. Myocardial adenosine triphosphate(ATP), phosphocreatine(PCr), inorganic phosphate(Pi), and intracellular pH in normal, hypothyroid and hyperthyroid rat hearts were measured using the pacing-gated ^<31>P nuclear magnetic resonance technique. Maximal decrease in ATP and PCr, and maximal increase in Pi at the peak-systele in normal rat hearts were observed. In hypothyroid and hyperthyroid rats, similar cyclical changes in phosphate metabolites were observed during the cycle. However, the magnitude of fluctuations was smaller in hypothyroid rats and larger in hyperthyroid rats compared with that observed in normal rats. Cardiac myosin isozyme patterns were also different amongst the experimental groups. The results suggest that cyelical changes and the magnitude of floctuations in energy-related phosphate metabolites during a cardiac cycle may depend on the cardiac workload and the intrinsic properties in the enzyme kinetics of myosin.
- 社団法人日本循環器学会の論文
- 2001-12-20
著者
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HANEDA TAKASHI
First Department of Internal Medicine, Asahikawa Medical College, Hokkaido, Japan
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TANAKA KUNIO
Central Laboratory for Research and Education, Asahikawa Medical College
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Haneda Takashi
First Department Of Internal Medicine Asahikawa Medical College
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Honda Hajime
First Department Of Lnternal Medicine Asahikawa Medical College
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Haneda Takashi
First Department Of Lnternal Medicine Asahikawa Medical College
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Akita Nobuyuki
First Department of lnternal Medicine, Asahikawa Medical College
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Akita Nobuyuki
First Department Of Lnternal Medicine Asahikawa Medical College
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Tanaka Kunio
Central Laboratory For Research And Education Asahikawa Medical College
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Tanaka Kunio
Central Laoratory For Research And Education Asahikawa Medical College
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