Protective Effect of the Angiotensin-Converting Enzyme Inhibitor Captopril on Postischemic Myocardial Damage in Perfused Rat Heart
スポンサーリンク
概要
- 論文の詳細を見る
This study was undertaken to examine whether a sulfhydryl-containing angiotensin-converting enzyme (ACE) inhibitor, captopril, improves postischemic cardiac function and myocardial metabolism in the perfused working rat heart, and to elucidate the mechanism by which captopril protects the myocardium from postischemic damage. Isolated rat hearts were perfused by the working heart technique for 15 min. Ischemia was then induced for 30 min by lowering the afterload pressure and coronary flow to zero. After ischemia, hearts were reperfused for 30 min by returning afterload pressure to 60 mmHg. Captopril, a non-sulfhydryl-containing ACE inhibitor, enalapril, or a type 1 angiotensin II receptor antagonist, DuP753, was added to the perfusate 5 min before ischemia, and the treatment was continued during the first 10-min period of reperfusion. In all groups there was no significant difference in pressure-rate product, coronary flow, tissue levels of ATP, total adenine nucleotides (TANs), energy charge potential (ECP), or creatine phosphate (CrP) before and during ischemia. During reperfusion following ischemia, captopril significantly improved the recovery of pressure-rate product, coronary flow, and tissue levels of ATP, TAN, ECP, and CrP, but neither enalapril nor DuP 753 had an effect. In conclusion, captopril improved postischemic cardiac function and myocardial metabolism in the perfused rat heart and its effect was independent of the blunting of angiotensin II formation.
- 社団法人日本循環器学会の論文
- 1997-07-20
著者
-
Kikuchi Kenjiro
First Department of Internal Medicine, Asahikawa Medical College
-
HANEDA TAKASHI
First Department of Internal Medicine, Asahikawa Medical College, Hokkaido, Japan
-
Haneda T
Nemuro Municipal Hospital
-
Haneda Takashi
旭川医科大学 内科学第1
-
Haneda Takashi
First Department Of Internal Medicine Asahikawa Medical College
-
Haneda Takashi
Nemuro Municipal Hospital
-
Kikuchi Kenjiro
First Department Of Internal Medicine Asahikawa Medical College
-
Takeda Hiroki
First Department Of Internal Medicine Asahikawa Medical College
-
Kikuchi Kenjiro
First Department Of Internal Medicine. Asahikawa Medical College
-
Takeda Hiroki
The First Department Of Internal Medicine Asahikawa Medical College
-
Haneda Takashi
The First Department Of Internal Medicine Asahikawa Medical College
関連論文
- OE-013 Decreased Susceptibility to Glomerular Regeneration in Thromboxane A2 Receptor Deficient Mice(Kidney/Renal circulation-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Comparison of myocardial fatty acid metabolism with left ventricular function and perfusion in cardiomyopathies : by ^I-BMIPP SPECT and ^Tc-tetrofosmin electrocardiographically gated SPECT
- Improved accuracy in estimation of left ventricular function parameters from QGS software with Tc-99m tetrofosmin gated-SPECT: a multivariate analysis.
- Electrophysiological Effects of Carvedilol on Rabbit Heart Pacemaker Cells
- Incidence of Cardiovascular Events in Patients with Dilated Phase of Hypertrophic Cardiomyopathy
- A Case of Cardiac Sarcoidosis : Significance of Ventricular Tachycardia Originating From thr Septum
- A case report of isolated levocardia without intracardiac anomalies associated with sick sinus syndrome
- PJ-795 Right heart MRI, as a New Modality for Assessment of Cor Pulmonale : Effects of Bosentan on Serious Pulmonary Hypertensive Patients(Pulmonary circulation-4 (H) PJ140,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Ja
- PJ-247 Phase-sensitive Reconstruction Method Secures Well-defined Myocardial Delayed Enhancement in MR Imaging in Patients with Cardiomyopathy(MRI/MRA-4 (I) PJ42,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circ
- PE-023 Delayed Enhancement of Cardiovascular Magnetic Resonance Imaging Indicates Electrically Damaged Myocardium in Idiopathic Cardiomyopathy with Ventricular Tachycardia(Arrhythmia, diagnosis/pathophysiology/EPS-6 (A) PE4,Poster Session (English),The 70
- OJ-126 Delayed Enhancement of Cardiovascular MRI Points out the Longest QT Interval Lead Producing Wide QT Dispersion in Hypertrophic Cardiomyopathy(ECG/Body surface potential mapping/Holter-2 (A) OJ21,Oral Presentation (Japanese),The 70th Anniversary Ann
- Effects of Local Inhibition of Nitric Oxide Synthesis on Myocardial Stunning
- Post-Ischemic Myocardial Dysfunction and Coronary Reserve in Left Ventricular Hypertrophy
- PJ-795 Right heart MRI, as a New Modality for Assessment of Cor Pulmonale : Effects of Bosentan on Serious Pulmonary Hypertensive Patients(Pulmonary circulation-4 (H) PJ140,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Ja
- PJ-247 Phase-sensitive Reconstruction Method Secures Well-defined Myocardial Delayed Enhancement in MR Imaging in Patients with Cardiomyopathy(MRI/MRA-4 (I) PJ42,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circ
- PE-023 Delayed Enhancement of Cardiovascular Magnetic Resonance Imaging Indicates Electrically Damaged Myocardium in Idiopathic Cardiomyopathy with Ventricular Tachycardia(Arrhythmia, diagnosis/pathophysiology/EPS-6 (A) PE4,Poster Session (English),The 70
- OJ-126 Delayed Enhancement of Cardiovascular MRI Points out the Longest QT Interval Lead Producing Wide QT Dispersion in Hypertrophic Cardiomyopathy(ECG/Body surface potential mapping/Holter-2 (A) OJ21,Oral Presentation (Japanese),The 70th Anniversary Ann
- Characteristics of Neuro-humoral Activation in Aged Heart Failure (Neurohumoral Factors 4 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Factors Affecting Acute Phase Proarrhythmia of Amiodarone (Arrhythmia, Pharmacological Therapy 3 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- BNP as a Significant Predictor of Restenosis after Percutaneous Coronary Intervention (Restenosis after Angioplasty, Basic/Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Diurnal ECG Changes Associated with Unusual Circadian Phythms of Sex Hormones in Brugada Syndrome with Atrial Flutter(Arrhythmia, Diagnosis/Pathophysiology/EPS 6 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-795 Right heart MRI, as a New Modality for Assessment of Cor Pulmonale : Effects of Bosentan on Serious Pulmonary Hypertensive Patients(Pulmonary circulation-4 (H) PJ140,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Ja
- PJ-247 Phase-sensitive Reconstruction Method Secures Well-defined Myocardial Delayed Enhancement in MR Imaging in Patients with Cardiomyopathy(MRI/MRA-4 (I) PJ42,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circ
- PE-023 Delayed Enhancement of Cardiovascular Magnetic Resonance Imaging Indicates Electrically Damaged Myocardium in Idiopathic Cardiomyopathy with Ventricular Tachycardia(Arrhythmia, diagnosis/pathophysiology/EPS-6 (A) PE4,Poster Session (English),The 70
- OJ-126 Delayed Enhancement of Cardiovascular MRI Points out the Longest QT Interval Lead Producing Wide QT Dispersion in Hypertrophic Cardiomyopathy(ECG/Body surface potential mapping/Holter-2 (A) OJ21,Oral Presentation (Japanese),The 70th Anniversary Ann
- PJ-795 Right heart MRI, as a New Modality for Assessment of Cor Pulmonale : Effects of Bosentan on Serious Pulmonary Hypertensive Patients(Pulmonary circulation-4 (H) PJ140,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Ja
- PJ-247 Phase-sensitive Reconstruction Method Secures Well-defined Myocardial Delayed Enhancement in MR Imaging in Patients with Cardiomyopathy(MRI/MRA-4 (I) PJ42,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circ
- PE-023 Delayed Enhancement of Cardiovascular Magnetic Resonance Imaging Indicates Electrically Damaged Myocardium in Idiopathic Cardiomyopathy with Ventricular Tachycardia(Arrhythmia, diagnosis/pathophysiology/EPS-6 (A) PE4,Poster Session (English),The 70
- OJ-126 Delayed Enhancement of Cardiovascular MRI Points out the Longest QT Interval Lead Producing Wide QT Dispersion in Hypertrophic Cardiomyopathy(ECG/Body surface potential mapping/Holter-2 (A) OJ21,Oral Presentation (Japanese),The 70th Anniversary Ann
- PJ-795 Right heart MRI, as a New Modality for Assessment of Cor Pulmonale : Effects of Bosentan on Serious Pulmonary Hypertensive Patients(Pulmonary circulation-4 (H) PJ140,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Ja
- PJ-247 Phase-sensitive Reconstruction Method Secures Well-defined Myocardial Delayed Enhancement in MR Imaging in Patients with Cardiomyopathy(MRI/MRA-4 (I) PJ42,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circ
- PE-023 Delayed Enhancement of Cardiovascular Magnetic Resonance Imaging Indicates Electrically Damaged Myocardium in Idiopathic Cardiomyopathy with Ventricular Tachycardia(Arrhythmia, diagnosis/pathophysiology/EPS-6 (A) PE4,Poster Session (English),The 70
- OJ-126 Delayed Enhancement of Cardiovascular MRI Points out the Longest QT Interval Lead Producing Wide QT Dispersion in Hypertrophic Cardiomyopathy(ECG/Body surface potential mapping/Holter-2 (A) OJ21,Oral Presentation (Japanese),The 70th Anniversary Ann
- Delayed Impact of Aging on Cardiac Sympathetic Nervous Activity in Female (Nuclear Cardiology 11(I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Relationship between the Effect of Intravenous Magnesium Therapy for the Ventricular Tachycardia and QT Dispersion Recovery
- Paradoxical Suppression of Angiotensin II-induced Vascular Remodeling in Impaired Glutathione Redox System(Atherosclerosis, Basic 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Thermal Treatment Attenuates Neointimal Thickening in Rat Femoral Artery with Enhanced Expression of HSP72 and Suppression of Oxidative Stress
- Treatment of Japanese Restless Legs Syndrome Patients with Cabergoline: An Open Clinical Preliminary Trial
- PJ-795 Right heart MRI, as a New Modality for Assessment of Cor Pulmonale : Effects of Bosentan on Serious Pulmonary Hypertensive Patients(Pulmonary circulation-4 (H) PJ140,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Ja
- PJ-247 Phase-sensitive Reconstruction Method Secures Well-defined Myocardial Delayed Enhancement in MR Imaging in Patients with Cardiomyopathy(MRI/MRA-4 (I) PJ42,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circ
- PE-023 Delayed Enhancement of Cardiovascular Magnetic Resonance Imaging Indicates Electrically Damaged Myocardium in Idiopathic Cardiomyopathy with Ventricular Tachycardia(Arrhythmia, diagnosis/pathophysiology/EPS-6 (A) PE4,Poster Session (English),The 70
- OJ-126 Delayed Enhancement of Cardiovascular MRI Points out the Longest QT Interval Lead Producing Wide QT Dispersion in Hypertrophic Cardiomyopathy(ECG/Body surface potential mapping/Holter-2 (A) OJ21,Oral Presentation (Japanese),The 70th Anniversary Ann
- PJ-795 Right heart MRI, as a New Modality for Assessment of Cor Pulmonale : Effects of Bosentan on Serious Pulmonary Hypertensive Patients(Pulmonary circulation-4 (H) PJ140,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Ja
- PJ-247 Phase-sensitive Reconstruction Method Secures Well-defined Myocardial Delayed Enhancement in MR Imaging in Patients with Cardiomyopathy(MRI/MRA-4 (I) PJ42,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circ
- PE-023 Delayed Enhancement of Cardiovascular Magnetic Resonance Imaging Indicates Electrically Damaged Myocardium in Idiopathic Cardiomyopathy with Ventricular Tachycardia(Arrhythmia, diagnosis/pathophysiology/EPS-6 (A) PE4,Poster Session (English),The 70
- OJ-126 Delayed Enhancement of Cardiovascular MRI Points out the Longest QT Interval Lead Producing Wide QT Dispersion in Hypertrophic Cardiomyopathy(ECG/Body surface potential mapping/Holter-2 (A) OJ21,Oral Presentation (Japanese),The 70th Anniversary Ann
- PJ-795 Right heart MRI, as a New Modality for Assessment of Cor Pulmonale : Effects of Bosentan on Serious Pulmonary Hypertensive Patients(Pulmonary circulation-4 (H) PJ140,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Ja
- PJ-247 Phase-sensitive Reconstruction Method Secures Well-defined Myocardial Delayed Enhancement in MR Imaging in Patients with Cardiomyopathy(MRI/MRA-4 (I) PJ42,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circ
- PE-023 Delayed Enhancement of Cardiovascular Magnetic Resonance Imaging Indicates Electrically Damaged Myocardium in Idiopathic Cardiomyopathy with Ventricular Tachycardia(Arrhythmia, diagnosis/pathophysiology/EPS-6 (A) PE4,Poster Session (English),The 70
- OJ-126 Delayed Enhancement of Cardiovascular MRI Points out the Longest QT Interval Lead Producing Wide QT Dispersion in Hypertrophic Cardiomyopathy(ECG/Body surface potential mapping/Holter-2 (A) OJ21,Oral Presentation (Japanese),The 70th Anniversary Ann
- PE-406 Percentage Area Stenosis and Residual Plaque as the Strong Predictor of In-Stent Restenosis for Small Coronary Arteries(Restenosis after Angioplasty, Basic/Clinical 4 (IHD) : PE69)(Poster Session (English))
- Percent Area Stenosis of Intravascular Ultrasound as the Best Predictor of In-Stent Restenosis
- Over 10 Years Benefits of β-Blockade Therapy in Patients with Dilated Cardiomyopathy
- Effect of Celiprolol on Cardiac Hypertrophy in Hypertension
- Effect of Celiprolol on Cardiac Hypertrophy in Hypertension
- -P295- Alteration in structural proteins in noninfarcted region during long survival after myocardial infarction.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -0658- significance of phoshorylation and dephosphorylation of desmin in ventricular remodeling after myocardial infarction(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -0180- The increase in the lipid peroxide contents in the rat myocardium exposed to hypoxia.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- CHANGE OF DESMIN CONTENT IN MYOCARDUM EXPOSED TO HYPOXIA : DOES THE DESMIN CONTENT CHANGE REVERSIBLY
- THE CHANGE OF STRUCTURAL PROTEINS IN NON-ISCHEMIC PART IN THE CHRONIC PHASE OF MYOCARDIAL FARCTION
- THE CHANGE OF STRUCTURAL PROTEINS AFTER REPERE FUSION : ANALYSIS WITH TWO-DIMENSIONAL ELECTROPHORESIS
- PJ-018 Brugada-type electrocardiographic changes during occlusion of the conus branch in patients with coronary artery disease(Arrhythmia, Diagnosis/Pathophysiology/EPS 5 (A) : PJ3)(Poster Session (Japanese))
- Mechanism of Endothelium-Dependent Vasorelaxation Evoked by Lysophosphatidylcholine
- The Role of Renal Dopamine in the Reduction of High Blood Pressure by β_1-Selective β-Blocker with Intrinsic Sympathomimetic Activity in Spontaneously Hypertensive Rats
- Comparison of 5-Hydroxytryptamine-Induced Contraction of Rat Pulmonary Artery to That of Aorta in Vitro
- Thrombolysis and Aspiration Thrombectomy Additively Improve the Clinical Outcome of PCI in Acute Myocardial Infarction(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 11 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Soc
- Attenuation of Ischemic Preconditioning Effects and Enhancement of Microvascular Damage in Acute Myocardial Infarction with Hypertension
- Significance of Reversed Redistribution in Exercise Thallium-201 SPECT Imaging in Patients with Vasospastic Angina
- Hybrid Re-Perfusion Therapy with Coronary Thrombolysis and PCIImproved the Clinical Outcome of Acute Myocardial Infarction (AMI)
- Renin-Angiotensin System Inhibitor Rescues Myocardial Apoptosis and Oxidative Damage Induced by Overwhelming β-adrenergic Stimulation
- PE-540 Safety of Sirolimus-eluting Stent Implantation for Patients with Acute Myocardial Infarction(Acute myocardial infarction, clinical (diagnosis/treatment)-7 (IHD) PE91,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Jap
- PE-089 Early Outcome of Sirolimus-eluting Stent Implantation for Patients with Acute Coronary Syndrome(Coronary revascularization, PCI-9 (IHD) PE15,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society
- OE-287 Differentiation of Acute Lesion from Chronic Myocardial Infarction by Combination of Delayed Enhancement and T2-Weighted Cardiac Magnetic Resonance Imaging(MRI/MRA-1 (I) OE48,Oral Presentation (English),The 70th Anniversary Annual Scientific Meetin
- PE-403 Role of Insulin Resistance to Restenosis after First Percutaneous Coronary Intervention(Restenosis after Angioplasty, Basic/Clinical 4 (IHD) : PE69)(Poster Session (English))
- Effects of Right Stellate Ganglion Block on the Autonomic Nervous Function of the Heart : A Study Using the Head-up Tilt Test
- -0980- IMMUNOHISTOCHEMICAL STUDY ABOUT EXPRESSION AND DISTURIBUTION OF CYTOSKELETAL PROTEINES IN CARDIOMYOPATHIC HAMUSTER HEARTS(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Transient Swelling of Peripheral Nerves in a Case of Neurosarcoidosis
- Plasma von Willebrand Factor Activities in Vascular Parkinsonism : Comparison With Parkinson's Disease
- PE-349 Ebselen, a glutathione peroxidase like antioxidant, activates ERK1/2 and SAPK/JNK, facilitating cardioprotection in ischemia-reperfusion(Cardiovascular Pharmacology, Basic/Clinical 3 (H) : PE60)(Poster Session (English))
- c-fos mRNA EXPRESSION COUPLES WITH cAMP-DEPERENDENT PROTEIN SYNTHESIS MECHANISM BY ACUTE PRESSURE OVERLOAD IN PERFUSED ADULT RAT HEART
- Cost-Effectiveness Analysis of Hypertension Treatment : Controlled Release Nifedipine and Candesartan Low-Dose Combination Therapy in Patients with Essential Hypertension : The Nifedipine and Candesartan Combination (NICE-Combi) Study
- Severe Pulmonary Hypertension Associated with Primary Sjogren's Syndrome
- Spontaneous Rupture of the Amyloid Spleen in a Case of Usual Interstitial Pneumonia
- Correlation of genetic etiology with response to β-adrenergic blockade among symptomatic patients with familial long-QT syndrome
- Effects of Long-term Oral Magnesium Treatment on Blood Pressure and Vascular Reactivity in Dahl Salt-Sensitive Rats
- Aldosterone Escape with Angiotensin Converting Enzyme Inhibitor is Diminished by Additive Angiotensin II Receptor Blockade in Essential Hypertension
- OJ-135 A Newly Estimated Glomerular Filtration Rate is an Independent Indicator of Arterial Stiffness(Atherosclerosis, clinical-4 (H) OJ23,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-615 Roles of Prostacyclin in Renin Elevation and Hypertension in Reno-vascular Hypertension and on Low Sodium Diet with Loop Diuretics(Hypertension, Basic and Clinical (H) : PJ103)(Poster Session (Japanese))
- PE-206 Role of Platelet Activity Regulated by Thromboxane A2 and Prostaglandin I2 in Glomerular Regeneration after Renal Ablation.(Kidney/Renal Circulation 1 (H) : PE35)(Poster Session (English))
- OJ-535 Prostagandin E_2 Suppresses Chemokines Production and Renal Fibrosis through the EP4 Receptor : Studies Using EP_4 Deficient Mice(Kidney/Renal Circulation 3 (H) : OJ65)(Oral Presentation (Japanese))
- Pulmonary Vein Ablation Causes Postganglionic Vagal Denervation Leaving Extraganglionic Sinus Node Control
- Reverse J-Curve Relation between Diastolic Blood Pressure and Severity of Coronary Artery Lesion in Hypertensive patients with Angina Pectoris
- Temocapril and olmesartan preserve myocardial fatty acid metabolism and sympathetic nervous activity in rats with chronic β-adrenergic stimulation
- Protective Effect of the Angiotensin-Converting Enzyme Inhibitor Captopril on Postischemic Myocardial Damage in Perfused Rat Heart
- Roles of Calcineurin (CaN) and Ca^/Calmodulin-Dependent Protein Kinase II (CaMKII) in Pressure-Induced Acceleration of Protein Synthesis in Adult Rat Heart
- -P302- The role of Adenosine in the Infarct Size Limiting Effect of Magnesium(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -0591- Does Inhibition of Nitric Oxide(NO)Enhance Postextrasystolic Potentiation(PESP)? : The role of Ca^ dependent mechanism(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Antioxidant Effects of Calcium Antagonists on Rat Myocardial Membrane Lipid Peroxidation
- Is left atrial enlargement a maker of progression of asymptomatic or minimally symptomatic aortic stenosis?
- Severe Pulmonary Hypertension Associated with Primary Sjogren's Syndrome