Treatment of Japanese Restless Legs Syndrome Patients with Cabergoline: An Open Clinical Preliminary Trial
スポンサーリンク
概要
- 論文の詳細を見る
Objective: To determine the effective dose of cabergoline in Japanese patients with restless legs syndrome (RLS). Methods: Six cases of idiopathic RLS and three of RLS with Parkinson disease (PD) participated in an open clinical preliminary trial. All cases were diagnosed based on the clinical criteria of the International RLS Study Group. Three RLS cases (1.3%) were detected out of 229 consecutive cases with PD. RLS severity was evaluated with International RLS Study Group (IRLSSG) Rating Scale Version 2.2 before and one year after the treatment with cabergoline. Results: For 6 idiopathic RLS patients, the IRLSSG questionnaire scores improved from 25.5±3.7 to 10.7±8.9 (p=0.028, Wilcoxon test) with 1 mg of daily cabergoline at the endpoint. For 3 RLS cases with PD, the score was 21.7±3.7 before the treatment, and RLS symptoms completely disappeared with 1 mg of cabergoline. One of RLS cases with PD required additional cabergoline later because of parkinsonism. No adverse event with cabergoline was reported in this study. Conclusion: One mg of daily cabergoline is effective in some Japanese patients of RLS.
- 社団法人 日本内科学会の論文
著者
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Kikuchi Kenjiro
First Department of Internal Medicine, Asahikawa Medical College
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Kikuchi Kenjiro
旭川医科大学 内科学循環呼吸神経病態内科学
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Enomoto Hiroyuki
Department of Neurology, National Douhoku Hospital
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Kimura Takashi
Department of Neurology, National Douhoku Hospital
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Yahara Osamu
Department of Neurology, National Douhoku Hospital
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Yahara Osamu
旭川医科大学 内科学第一講座
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Aizawa Hitoshi
First Department of Medicine, Asahikawa Medical College
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Aburakawa Yoko
First Department of Medicine, Asahikawa Medical College
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Suzuki Yasuhiro
First Department of Medicine, Asahikawa Medical College
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Makita Yoshihiro
First Department of Medicine, Asahikawa Medical College
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Kikuchi Kenjiro
First Department Of Internal Medicine Asahikawa Medical College
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Enomoto Hiroyuki
Department Of Applied Chemistry Faculty Of Engineering Osaka Electro-communication University
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Aizawa Hitoshi
First Department of Internal Medicine, Section of Neurology, Asahikawa Medical College
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KIMURA Takashi
Department of Cardiovascular, Respiratory and Metabolic Medicine Graduate School of Medicine, Kagoshima University
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Yahara Osamu
Department of Neurology, Asahikawa Medical Center, Japan
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Kikuchi Kenjiro
First Department of Medicine, Asahikawa Medical College
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