EFFECTS OF REGRESSION OF LEFT VENTRICULAR HYPERTROPHY FOLLOWING ATENOLOL OR BUNAZOSIN THERAPY ON ISCHEMIC CARDIAC FUNCTION AND MYOCARDIAL METABOLISM IN SPONTANEOUSLY HYPERTENSIVE RATS
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概要
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The effects of regression of left ventricular hypertrophy following atenolol and bunazosin therapy on ischemic cardiac function and myocardial metabolism in spontaneously hypertensive rats (SHR) were studied. Atenolol (50mg/kg/day) and bunazosin (5mg/kg/day) were administered to SHR from 19 to 26 weeks of age, whereas tap water was given to control SHR and normotensive Wistar-Kyoto rats (WKY). Both atenolol and bunazosin significantly decreased arterial blood pressure and significantly decelerated the increase in left ventricular weight in SHR. At the end of the long-term treatment, hearts were removed and perfused by the working heart technique for 15 min. and then global ischemia was induced for either 10 or 30 min. The ischemic heart was reperfused for 30 min. The pressure-rate product and the extent of recovery of the coronary flow after reperfusion following 30 min of ischemia in the bunazosin-treated SHR were significantly higher than those in the control SHR and the atenolol-treated SHR. The levels of adenosine triphosphate (ATP). creatine phosphate (CrP). and energy charge potential in the SHR heart reperfused after 30 min of ischemia were significantly lower than those in the reperfused WKY. Both atenolol and bunazosin improved the restoration of ATP and CrP in SHR after reperfusion following 30min of ischemia. In conclusion. antihypertensive therapy with either atenolol or bunazosin was effective in preventing cardiac hypertrophy and ischemic damage caused by different mechanisms. Factors resulting from stimulation of the cardiac alpha_1 adrenoceptor may play an important role in the development of hypertensive cardiac hypertrophy, just as factors resulting from stimulation of the β_1-adrenoceptor do.
- 社団法人日本循環器学会の論文
- 1991-12-20
著者
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HANEDA TAKASHI
First Department of Internal Medicine, Asahikawa Medical College, Hokkaido, Japan
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Haneda T
First Department Of Internal Medicine Asahikawa Medical College
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TANAKA Hideichi
Nayoro City Hospital
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Obata Hiromi
First Department of Internal Medicine, Asahikawa Medical College
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Haneda Takashi
First Department Of Internal Medicine Asahikawa Medical College
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Hirayama Tomoya
旭川医科大学 1内
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Haneda Takashi
Nemuro Municipal Hospital
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Obata Hiromi
First Department Of Internal Medicine Asahikawa Medical College
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TANAKA Hideichi
First Department of Internal Medicine,Asahikawa Medical College
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Tanaka Hideichi
First Department Of Internal Mediccine Asahikawa Medical College
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Tanaka Hideichi
First Department Of Internal Medicine Asahikawa Medical College
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Tanaka Hideichi
The First Department Of Internal Medicine Asahikawa Medical College
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Obata Hiromi
First Department Of Internal Mediccine Asahikawa Medical College
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Tanaka Hideichi
Division Of Cardiology Hokkaido Cardiovascular Hospital
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Obara Hiromi
The First Department Of Internal Medicine Asahikawa Medical College
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Haneda Takashi
1st Department Of Internal Medicine Asahikawa Medical College
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