Effect of captopril treatment on proteinuria in NZB/NZW F1 hybrid mice.

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概要

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• Oral treatment of female NZB/NZW F<SUB>1</SUB> hybrid mice with captopril prevented the development of proteinuria and prolonged survival in mice demonstrating slight (trace to 1+) proteinuria. Captopril treatment also markedly reduced the incidence and magnitude of proteinuria and prevented death in mice showing significant (3+ or greater) proteinuria. Histopathological studies of the kidneys of treated mice further demonstrated improvements in the renal lesions of autoimmune mice. The mechanisms whereby captopril treatment influences the course of disease in NZB/NZW mice are not known.

• 公益社団法人 日本薬理学会の論文

著者

• Fukami Masaharu

  Biological Research Laboratories Sankyo Co. Ltd.

• KITAMURA Kouichi

  Biological Research Laboratories, Sankyo Co., Ltd.

• FUKAMI Masaharu

  Biological Research Laboratories, Sankyo Co., Ltd.

• KURAKATA Shinichi

  Biological Research Laboratories, Sankyo Co., Ltd.

関連論文

• IMPROVEMENT OF BIOAVAILABILITY OF POORLY ABSORBED DRUGS. III. ORAL ACUTE TOXICITY AND LOCAL IRRITATION OF MEDIUM CHAIN GLYCERIDE
• Effects of Pravastatin Sodium Alone and in Combination with Cholestyramine on Hepatic, Intestinal and Adrenal Low Density Lipoprotein Receptors in Homozygous Watanabe Heritable Hyperlipidemic Rabbits.
• Effect of captopril treatment on proteinuria in NZB/NZW F1 hybrid mice.

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