Gastric Carcinogenesis and Intestinalization Induced by N-methyl-N-nitrosourea in the Senescence-Accelerated Mouse (SAMP3)

スポンサーリンク

概要

• 論文の詳細を見る

• The relationship between gastric neoplasia and intestinal metaplasia, a process whose incidence increases with age, remains controversial. In the present experiment, we therefore investigated induction of both intestinal metaplasia and gastric cancers in the Senescence-accelerated mouse (SAMP3/Aicc) treated with N-methyl-N-nitrosourea (MNU). Seven-week-old animals of both sexes received the carcinogen in their drinking water at 120 or 60 ppm on alternative weeks for 10 weeks, or continuously at 30 ppm for the same period, then maintained without further treatment until sacrificed at week 50. The incidences of adenocarcinomas in the 120, 60, and 30 ppm MNU treated and control groups were 6/10 (60%), 5/16 (31.3%), 1/17 (5.9%), and 0/6 (0%) in males, and 2/7 (28.6%), 3/13 (23.1%), 1/6 (16.7%), and 0/9 (0%) in females, respectively. All neoplasms were of well-differentiated type, mainly consisting of gastric epithelial type cells. With immuno- and enzyme-histochemistry, intestinal alkaline phosphatase (I-ALP) positive intestinal absorptive cell-like elements were observed in regions of hyperplasia, adenomas, and adenocarcinomas of MNU treated mice, but no phenotypic expression of goblet or Paneth cells was found. In the control mice, gastric mucosa showed no intestinal epithelium phenotype. Since the degree of appearance of I-ALP positive cells in the lesions in SAMP3/Aicc mice was not different from that found for six other strains mice in our previous work, the results suggest that Senescence-acceleration may not influence intestinalization in the gastric mucosa or induction of gastric carcinomas.

• 日本毒性病理学会の論文
• 2003-03-30

著者

• Tatematsu M

  Division Of Oncological Pathology Aichi Cancer Center Research Institute

• Tsukamoto T

  Division Of Oncological Pathology Aichi Cancer Center Research Institute

• TSUKAMOTO Tetsuya

  Division of Oncological Pathology, Aichi Cancer Center Research Institute

• HIRATA Akihiro

  Division of Oncological Pathology, Aichi Cancer Center Research Institute

• YAMAMOTO Masami

  Division of Oncological Pathology, Aichi Cancer Center Research Institute

• SAKAI Hiroki

  Department of Veterinary Pathology, Gifu University

• YANAI Tokuma

  Department of Veterinary Pathology, Gifu University

• MASEGI Toshiaki

  Department of Veterinary Pathology, Gifu University

• TATEMATSU Masae

  Division of Oncological Pathology, Aichi Cancer Center Research Institute

• HIRATA Akihiro

  Department of Veterinary Pathology, Gifu University

• HIRANO Kazuyuki

  Laboratory of Pharmaceutics, Gifu Pharmaceutical University

• FURIHATA Chie

  College of Science and Engineering, Aoyama Gakuin University

• 坂井 宏明

  帯広畜産大学畜産学部獣医学科家畜内科学教室

• Yanai T

  Department Of Veterinary Pathology Gifu University

• Totsuka Yukari

  大阪府立大学先端科学イノベーションセンター 遺伝子環境科学研究室

• Totsuka Y

  Cancer Prevention Basic Research Project

• Tatematsu Masae

  Division Of Oncological Pathology Aichi Cancer Center Research Institute

• Tatematsu M

  愛知県がんセンター研究所 腫瘍病理学部

• Tsukamoto Tetsuya

  Division Of Oncological Pathology Aichi Cancer Center Research Institute

• 高岡 雅哉

  Medicinal Safety Research Laboratories Daiichi-sankyo Co. Ltd.

• Yanai Tokuma

  Department Of Veterinary Pathology Faculty Of Agriculture Gifu University

• Tatematsu Masae

  愛知県がんセンター研究所 腫瘍病理学部

• Yamachika Takasuke

  Division Of Oncological Pathology Aichi Cancer Center Research Institute

• Tajika Masahiro

  Department Of Gastroenterology Aichi Cancer Center Hospital

• Takaoka Masaya

  Medicinal Safety Research Laboratories Daiichi-sankyo Co. Ltd.

• Hirano Kazuyuki

  Laboratory Of Pharmaceutics Gifu Pharmaceutical University

• Makino Toshihiko

  Medicinal Safety Research Laboratories Daiichi Sankyo Co. Ltd.:department Of Veterinary Pathology Gr

• Tsukamoto Takahisa

  First Department Of Oral And Maxillofacial Surgery School Of Dentistry

• Mizoshita Tsutomu

  Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie

• Yamamoto M

  Aichi Cancer Center Research Institute

• Tsukamoto Takahisa

  Division Of Oncological Pathology Aichi Cancer Center Research Institute

• Furihata Chie

  College Of Science And Engineering Aoyama Gakuin University

• Masegi Toshiaki

  Department Of Veterinary Pathology Faculty Of Agriculture Gifu University

• Tsukamoto T

  Department Of Public Health Osaka City University Graduate School Of Medicine

• Totsuka Yukari

  国立がん研究センター研究所 発がんシステム研究分野

• Masegi Toshiaki

  Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie

• Sakai Hiroki

  Department Of Food Science Niigata University Of Pharmacy And Applied Life Sciences

• Makita Takashi

  Dept. Vet. Anat. Yamaguchi Univ.

• Makita Takashi

  Medicinal Safety Research Laboratories Daiichi Sankyo Co. Ltd.:department Of Veterinary Pathology Gr

• YANAI Tokuma

  Department of Pathogenetic Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan

• HIRATA Akihiro

  Department of Veterinary Pathology, Faculty of Agriculture, Gifu University

関連論文

• Retroperitoneal Fibromatosis in a Cynomolgus Monkey (Macaca fascicularis)
• Frequent Development of Inflammatory Lesions and Lymphoid Foci in the Kidneys of Japanese Wild Crows (Corvus macrorhynchos and Corvus corone) as a Result of the Entry of Causal Agents via the Renal Portal Blood
• Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and β-catenin activation in gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic mice
• Lack of association between CpG island methylator phenotype in human gastric cancers and methylation in their background non-cancerous gastric mucosae
• Inhibitory effect of nordihydroguaiaretic acid, a plant lignan, on Helicobacter pylori-associated gastric carcinogenesis in Mongolian gerbils
• Organ-dependent susceptibility of p53 knockout mice to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)
• Gastric adenocarcinoma with chief cell differentiation
• Effects of eradication of Helicobacter pylori on gastric carcinogenesis in experimental models
• Helicobacter pylori infection stimulates intestinalization of endocrine cells in glandular stomach of Mongolian gerbils
• Significant Factors on Gastric Carcinogenesis Revealed by Experimental Animal Models
• Gastric and intestinal phenotypes and histogenesis of advanced glandular stomach cancers in carcinogen-treated, Helicobacter pylori-infected Mongolian gerbils
• Colonic and small-intestinal phenotypes in gastric cancers : Relationships with clinicopathological findings
• Susceptibility of Heterozygous and Nullizygous p53 Knockout Mice to Chemical Carcinogens : Tissue Dependence and Role of p53 Gene Mutations
• Coexistence of gastric-and intestinal-type endocrine cells in gastric and intestinal mixed intestinal metaplasia of the human stomach
• Eradication of Helicobacter pylori induces apoptosis and inhibits proliferation of heterotopic proliferative glands in infected Mongolian gerbils
• P6-38 Relationship between hepatic enzyme induction and carcinogenicity in the p53 deficient mice treated with aminophenylnorharman(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
• β-Catenin gene alteration in glandular stomach adenocarcinomas in N-methyl-N-nitrosourea-treated and Helicobacter pylori-infected Mongolian gerbils
• Immunohistochemically detectable Cdx2 is present in intestinal phenotypic elements in early gastric cancers of both differentiated and undifferentiated types, with no correlation to non-neoplastic surrounding mucosa
• Detection of Initiating and Promoting Activity of Aminophenylnorharman with a Five-week In Vivo Initiation Assay
• Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation
• β-Catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas
• Tissue-dependent susceptibility of p53 knockout mice to chemical-induced carcinogenesis (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• Effect of early eradication on Helicobacter pyloirirelated gastric carcinogenesis in Mongolian gerbils
• Gastric Carcinogenesis and Intestinalization Induced by N-methyl-N-nitrosourea in the Senescence-Accelerated Mouse (SAMP3)
• Earlier Helicobacter pylori Infection Increases the Risk for the N-Methyl-N-nitrosourea-induced Stomach Carcinogenesis in Mongolian Gerbils
• Tongue Carcinogenic Susceptibility of p53 Deficient Mice to Methyl-n-amylnitrosamine
• Cloning of the 5' Upstream Region of the Rat p16 Gene and Its Role in Silencing
• Synergistic Promoting Effects of Helicobacter pylori Infection and High-salt Diet on Gastric Carcinogenesis in Mongolian Gerbils
• Lack of a Dose-response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-Nitrosodiethylamine
• Appearance of Osteonectin-expressing Fibroblastic Cells in Early Rat Stomach Carcinogenesis and Stomach Tumors Induced with N-Methyl-N'-nitro-N-nitrosoguanidine
• The Effects of Allyl Alcohol-induced Cell Proliferation for Detection of Initiation Activities of Chemicals in Rat Liver
• Preneoplastic Changes of Stomach Cancer : Mice, Rats and Mongolian Gerbils
• Reversibility of Heterotopic Proliferative Glands in Glandular Stomach of Helicobacter pylori-infected Mongolian Gerbils on Eradication
• The Effects of D-galactosamine- or Carbon Tetrachloride-Induced Regeneration on Induction of Rat Liver Cell Foci in a Model for Detection of Initiation Activities of Chemicals
• Differential Effects of Partial Hepatectomy and Carbon Tetrachloride Administration on Induction of Liver Cell Foci in a Model for Detection of Initiation Activity
• More Frequent β-Catenin Gene Mutations in Adenomas than in Aberrant Crypt Foci or Adenocarcinomas in the Large Intestines of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-treated Rats
• Mouse Strain Susceptibility to Diethylnitrosamine Induced Hepatocarcinogenesis Is Cell Autonomous Whereas Sex-susceptibility Is Due to the Micro-environment:Analysis with C3H【tautomer】BALB/c Sexually Chimeric Mice
• New animal model of glandular stomach carcinogenesis in Mongolian gerbils infected with Helicobacter pylori and treated with a chemical carcinogen
• Development and Distribution of 2-Amino- 1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP)-induced Aberrant Crypt Foci in the Rat Large Intestine
• Increased Expression of Sucrase and Intestinal-type Alkaline Phosphatase in Human Gastric Carcinomas with Progression.
• Expression of Sucrase and Intestinal-type Alkaline Phosphatase in Colorectal Carcinomas in Rats Treated with Methylazoxymethanol Acetate.
• Stable Expression of Glutathione S-transferase P-form mRNA and TGF-α Immunohistochemical Expression are Useful Markers for Identification of Persistent Nodules from an Early Stage in Rat Hepatocarcinogenesis
• N-Methyl-N-nitrosourea Concentration-dependent, Rather than Total Intake-dependent, Induction of Adenocarcinomas in the Glandular Stomach of BALB/c Mice
• Increased Expression of Sucrase and Intestinal-type Alkaline Phosphatase in Human Gastric Carcinomas with Progression
• Dose-dependent Promoting Effects of Catechol on Glandular Stomach Carcinogenesis in BALB/c Mice Initiated with N-Methyl-N-nitrosourea
• Sparse Distribution of Hepatocyte Growth Factor-producing Cells inside Hepatocellular Foci in Rats Treated with Hepatocarcinogens
• Gastric tumorigenicity of 1,2-dimethylhydrazine on the background of gastric intestinal metaplasia induced by X-irradiation in CD (SD) rats.
• Gastric Tumorigenicity of 1,2-Dimethylhydrazine on the Background of Gastric Intestinal Metaplasia Induced by X-Irradiation in CD (SD) Rats
• Cloning of the 5' Upstream Region of the Rat p16 Gene and Its Role in Silencing
• Appearance of Osteonectin-expressing Fibroblastic Cells in Early Rat Stomach Carcinogenesis and Stomach Tumors Induced with N-Methyl-N'-nitro-N-nitrosoguanidine
• Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N-butyl-N-(4-hydroxybutyl) nitrosamine in rats after initiation
• Lung as a new target in rats of 2-amino-3-methylimidazo[4,5-f]quinoline carcinogenesis : Results of a two-stage model initiated with N-bis(2-hydroxypropyl)nitrosamine
• Growth characteristics of canine distemper virus in a new cell line CCT cells originated from canine malignant histiocytosis
• A polymorphism of C-to-T substitution at -31 IL1B is associated with the risk of advanced gastric adenocarcinoma in a Japanese population
• Inhibition of Helicobacter pylori Motility by (+)-Syringaresinol from Unripe Japanese Apricot(Medicinal Chemistry)
• Establishment and characterization of a human colonic mucinous carcinoma cell line with predominant goblet-cell differentiation from liver metastasis
• EFFECTS OF ATROPINE SULFATE ON RAT HARDERIAN GLANDS : CORRELATION BETWEEN MORPHOLOGICAL CHANGES AND PORPHYRIN LEVELS
• Collaborative work on evaluation of ovarian toxicity : 8) Two- or four-week repeated-dose studies and fertility study of Anastrozole in female rats
• Age-Related Changes in Thyroid Lesions and Function in F344/DuCrj Rats
• Ganglioneuroma in the Urinary Bladder of a Dog
• Expression of Cathepsin E and Its Suppression with Intestinalization in Epithelial Cells and Tumor Cells in Rat Glandular Stomach Treated with N-methyl-N-nitro-N-nitrosoguanidine
• STEM CELLS AND GASTRIC CANCER : ROLE OF GASTRIC AND INTESTINAL MIXED INTESTINAL METAPLASIA
• Stem cells and gastric cancer : Role of gastric and intestinal mixed intestinal metaplasia
• Difference in Target Organs in Carcinogenesis with a Heterocyclic Amine, 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline, in Different Strains of Mice
• IMMUNOHISTOCHEMICAL STUDIES OF TSH-PRODUCING CELLS IN THE PITUITARY AND EXPRESSION OF GROWTH FACTORS IN THYROIDAL PROLIF-ERATIVE LESIONS IN RATS TREATED WITH THIOUREA AND EXCESS VITAMIN A
• Risk factors for vitamin D deficiency in patients with Crohn's disease
• Immunopathogenesis of hepatic fibrosis in chronic liver injur induced by repeatedly administered concanavalin A
• Point Mutations of the c-H-ras Gene in Spontaneous Pulmonary Tumors of Transgenic Mice Carrying the Human c-H-ras Gene
• Improvement of fuel metabolism by nocturnal energy supplementation in patients with liver cirrhosis
• Diagnosis of autoimmune pancreatitis using endoscopic ultrasonography
• Significance of CXCR3 expression in gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue type for predicting responsiveness to Helicobacter pylori eradication
• LONG-TERM FOLLOW UP OF PATIENTS WITH SMALL GASTROINTESTINAL STROMAL TUMORS IN THE STOMACH USING ENDOSCOPIC ULTRASONOGRAPHY-GUIDED FINE-NEEDLE ASPIRATION BIOPSY
• ENDOSCOPIC ULTRASONOGRAPHY-GUIDED FINE-NEEDLE ASPIRATION BIOPSY : A SAFE METHOD FOR ACCURATE DIAGNOSIS
• Nutritional pharmacotherapy of chronic liver disease : from support of liver failure to prevention of liver cancer
• Preferential Use of Branched-Chain Amino Acids as an Energy Substrate in Patients with Liver Cirrhosis
• Chemosensitivity of peritoneal micrometastases as evaluated using a green fluorescence protein (GFP)-tagged human gastric cancer cell line
• 後躯不全麻痺を示したフェレットの椎骨に発生した線維肉腫の1例
• Progesterone Enhancement of Stomach Tumor Development in SD Rats Treated with N-Methyl-N'-nitro-N-nitrosoguanidine
• Detection of Carcinoembryonic Antigen-expressing Free Tumor Cells in Peritoneal Washes from Patients with Gastric Carcinoma by Polymerase Chain Reaction
• Detection of Initiation Activity of 1,2-dimethylhydrazine in in Vivo Medium-Term Liver Initiation Assay System Using 4-Week-Old Rats without Hepatocellular Proliferative Stimuli during the Test Chemical Treatment Period
• Osteosarcomas in the Lungs of an ICR Mouse
• Evaluation of Cell Proliferation in Canine Tumors by the Bromodeoxyuridine Labeling Method, Immunostaining of Ki-67 Antigen and Proliferating Cell Nuclear Antigen
• Immunohistochemical Demonstration of S-phase Cells in Canine and Feline Spontaneous Tumors by Anti-bromodeoxyuridine Monoclonal Antibody
• イヌのエプーリスに関する臨床病理学的研究
• LARGE AMOUNT OF VITAMIN A HAS NO MAJOR EFFECTS ON THYROIDAL HORMONE SYNTHESIS IN TWO-STAGE RAT THYROID CARCINOGENESIS MODEL USING N-BIS(2-HYDROXYPROPYL)NITROSAMINE AND THIOUREA
• Solitary bone metastasis as the first clinical manifestation in a patient with small bowel adenocarcinoma
• Hexosaminidase-altered Aberrant Crypts, Carrying Decreased Hexosaminidase α and β Subunit mRNAS, in Colon of 1,2-Dimethylhydrazine-treated Rats
• Immunohistochemical Staining Methods for Connexin32 on Formalin-Fixed Paraffin-Embedded Sections
• Pulmonary Histiocytic Sarcoma in Two Aged Dogs of a Beagle Colony
• Gastric carcinogenesis by N-Methyl-N-Nitrosourea is enhanced in db/db diabetic mice
• Dendritic Cell Appearance and Differentiation during Early and Late Stages of Rat Stomach Carcinogenesis
• Serum tumor antigen REG4 as a diagnostic biomarker in pancreatic ductal adenocarcinoma
• Clinical impact of radiotherapy for locally advanced pancreatic cancer
• Proliferative Potential of a Spinal Nephroblastoma in a Young Dog
• Antihypertensive and Vasorelaxant Effects of Water-Soluble Proanthocyanidins from Persimmon Leaf Tea in Spontaneously Hypertensive Rats
• Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in rats : Evidence for the existence of no-effect levels and a mechanism involving p21^
• Antihypertensive and Vasorelaxant Effects of Water-Soluble Proanthocyanidins from Persimmon Leaf Tea in Spontaneously Hypertensive Rats
• Proliferative Potential of a Spinal Nephroblastoma in a Young Dog
• Expression of Cathepsin E and Its Suppression with Intestinalization in Epithelial Cells and Tumor Cells in Rat Glandular Stomach Treated with N-methyl-N'-nitro-N-nitrosoguanidine
• Preneoplastic Changes of Stomach Cancer. Mice, Rats and Mongolian Gerbils.:—Mice, Rats and Mongolian Gerbils—

もっと見る 閉じる

スポンサーリンク