Diverse Pathogenicity of Equine Herpesvirus 1 (EHV-1) Isolates in CBA Mouse Model
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概要
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The pathogenicity of equine herpesvirus 1 (EHV-1) isolates of Japan were evaluated by using the CBA mouse model. CBA mice were inoculated with eight Japanese EHV-1 strains (89c1, 90c16, 90c18, 97c11, 98c12, 00c19, 01c1 and HH-1) and one British strain (Ab4p). 89c1 caused slight body weight loss and nervous signs in mice at 8 days post infection (dpi). Severe weight loss and nervous signs were observed in mice inoculated with Ab4p at 6 dpi. The other strains did not cause apparent clinical signs. Infectious viruses were recovered from the lungs of all groups at 2 dpi. Histopathological analysis revealed interstitial pneumonia in the lungs of all mice inoculated with EHV-1. Encephalitis or meningoencephalitis was observed in the brains of mice inoculated with 89c1, 90c18, 97c11, 98c12, 01c1 and Ab4p. Japanese EHV-1 strains showed low pathogenicity in CBA mice, whereas the sequential affects of infection are similar to those of the highly pathogenic strain Ab4p. These results suggest that field isolates of EHV-1 have varying degrees of pathogenicity in CBA mice.
著者
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FUKUSHI Hideto
Department of Applied Veterinary Science, United Graduate School of Veterinary Sciences
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Yu Mi
Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu Unive
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Kasem Samy
Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu Unive
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Tsujimura Koji
Molecular Biology Division, Epizootic Research Center, Equine Research Institute, Japan Racing Assoc
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MATSUMURA Tomio
Molecular Biology Division, Epizootic Research Center, Equine Research Institute, Japan Racing Assoc
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YANAI Tokuma
Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University
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YAMAGUCHI Tsuyoshi
The Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University
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OHYA Kenji
Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu Unive
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Matsumura Tomio
Molecular Biology Division Epizootic Research Center Equine Research Institute Japan Racing Associat
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Yamaguchi Tsuyoshi
The Avian Zoonosis Research Center Faculty Of Agriculture Tottori University
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Ohya Kenji
Department of Applied Chemistry, Faculty of Engineering, Utsunomiya University
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YANAI Tokuma
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University
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YU Mi
Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University
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