New Retinoids Inhibiting the Growth of Human Acute Promyelocytic Leukemia Cell Line HL-60 without Inducing Differentiation.
スポンサーリンク
概要
- 論文の詳細を見る
A series of acid homologs with longer side chain length was synthesized and their biological activities to inhibit growth and to induce differentiation of human acute promyelocytic leukemia cell line HL-60 were analyzed. It was found that ethyl α-retinylidene propionate (E) shows interesting activity. This compound inhibited growth of HL-60 cells with almost the same potency of retinoic acid. However, unlike retinoic acid, the potency of this compound to induce differentiation of HL-60 cells into neutrophiles was almost negligible. Ethyl α-retinylidene propionate (E) is an unprecedented retinoid which inhibits growth of HL-60 cells without inducing cell differentiation. The Z isomer [ethyl α-retinylidene propionate (Z)] also showed similar unique effects on HL-60 cells. Interestingly, both of the E and Z isomers of α-retinylidene propionic acid showed only very weak activities to inhibit growth and to induce differentiation of HL-60 cells. It was suggested that ethyl α-retinylidene propionate acts on HL-60 cells in the intact form without suffering hydrolysis, and also that the ester group plays important role for the unique activity. Biological activities of retinylidene acetic acid (E and Z) which lacks methyl group at α-position of α-retinylidene propionic acid, on HL-60 cells were weaker than those of the isomers of α-retinylidene propionic acid. Esterification of the isomers of retinylidene acetic acid resulted in further decrease of biological activities. Biological activities of ethyl retinoate on HL-60 cells were also very weak. It was indicated that methyl group present at a-position of ethyl α-retinylidene propionate plays an important role for the unique biological activity. It was further indicated that the effect of esterification of carboxyl group of retinoids on the biological activity is not constant, but varies depending on the structure. Pretreatment of HL-60 cells with ethyl α-retinylidene propionate (E) apparently did not influence the process of induction of differentiation of HL-60 cells into neutrophiles by retinoic acid. It was further shown that ethyl α-retinylidene propionate (E) prolongs the time necessary for induction of differentiation of HL-60 cells by retinoic acid, but does not influence the level of final rate of differentiation.
- 財団法人 学会誌刊行センターの論文
著者
-
Matsui Masanao
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
-
SUZUKI Takakazu
Department of Clinical Genetics (II), The Tokyo Metropolitan Institute fo Medical Science
-
MURAYAMA Akira
Department of Agriculture, The University of Tokyo
-
KAWAMURA Seiji
Department of Agriculture, The University of Tokyo
関連論文
- The Effect of Probucol on Atherosclerosis in Streptozotocin-Induced Diabetic-Hyperlipidemic APA Hamsters in Different Stages of Atherosclerosis
- No Regional Differences of Cytochrome P450 Expression in the Liver of Cynomolgus Monkeys (Macaca fascicularis)
- D-Galactosamine Induced Hepatocyte Apoptosis is Inhabited in vivo and in Cell Culture by a Calcium Calmodulin Antagonist, Chlorpromazine, and a Calcium Channel Blocker, Verapamil
- Renal Function Tests on Diabetes-Induced and Non-Induced APA Hamsters
- Expression of Lipoprotein Receptors in the Aortic Walls of Diabetic APA hamsters
- Functional and Histochemical Analysis on Pancreatic lslets of APA Hamsters with SZ-Induced Hyperglycemia and Hyperlipidemia
- APA Hamster Model for Diabetic Atherosclerosis. 2. Analysis of Lipids and Lipoproteins
- Aortic Atheromatous Lesions Developed in APA Hamsters with Streptozotocin induced Diabetes: A New Animal Model for Diabetic Atherosclerosis. 1. Histopathological Studies
- Localization and Age-Related Changes in Cytochrome P450 Expression in APA Hamster Livers
- 心エコーによるLipo-PGE1抵抗性動脈管形態の検討
- Differences between BALB/c and C57BL/6 Mice in Mouse Hepatitis Virus Replication in Primary Hepatocyte Culture
- A NEW APPROACH TO NONIVASIVE CORONARY ARTERY VISUALIZATION USING CROSS SECTIONAL ECHOCARDIOGRAPHY : Echocardiography I : IIIrd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- Cryopreservation of Brain Tissue for Primary Culture
- EFFECTS OF T-2 TOXIN ON HEPATOCYTE PROLIFERATION IN NORMAL MICE
- Peripheral blood extrathymic CD4^+CD8^+ T cells with high cytotoxic activity are from the same lineage as CD^+CD8^- T cells in cynomolgus monkeys
- Lateral Position Prevents Respiratory Occlusion during Surgical Procedure under General Anesthesia in the Patient of Huge Anterior Mediastinal Lymphoblastic Lymphoma
- Biological activity of pestalotins on the elongation growth of rice seedlings
- Myocardial ischemia due to vascular systemic amyloidosis : A quantitative analysis of autopsy findings on stenosis of the intramural coronary arteries
- B-1-5 Recent Problems on Chrysanthemic Acids(Terpenoids)
- Senile Plaques in an Aged Western Lowland Gorilla
- B-10-5 Synthesis of Substances related to Gibberellins(Terpenoids)
- Development of Intestinal Flora of Human-Flora-Associated (HFA) Mice in the Intestine of their Offspring
- Secondary arteriovenous fistula after a single arterial puncture
- Effect of Novel Analogs of the Juvenile Hormone. : I. Effect of Juvenile Hormone Analogs with Different Alkyl Substituents at C-7 and C-11 on the Silkworm, Bombyx mori L. (Lepidoptera : Bombycidae)
- PULMONARY EMBOLISM AND HEMOLYTIC ANEMIA IN A PATIENT WITH COLD AGGLUTININ DISEASE
- Photoisomerization of Retinoic Acids in Ethanol under Room Light: A Warning for Cell Biological Study of Geometrical Isomers of Retinoids
- Molecular Flexibility of Retinoic Acid under White Fluorescent Light
- Biological Effect of 9-cis-Retinoic Acid and 9,13-di-cis-Retinoic Acid on Human Acute Promyelocytic Leukemia Cell Line HL-60.
- An Efficient Synthesis of Methyl Jasmonate and Methyl Dihydrojasmonate
- Biological Activity of (all-E)-.BETA.-Apo-12'-carotenoic Acid and the Geometrical Isomers on Human Acute Promyelocytic Leukemia Cell Line HL-60.
- New Retinoids Inhibiting the Growth of Human Acute Promyelocytic Leukemia Cell Line HL-60 without Inducing Differentiation.