Biological Effect of 9-cis-Retinoic Acid and 9,13-di-cis-Retinoic Acid on Human Acute Promyelocytic Leukemia Cell Line HL-60.
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概要
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9-cis-Retinoic acid and 9, 13-di-cis-retinoic acid were synthesized and their biological effects on human acute promyelocytic cell line HL-60 were analyzed. 9-cis-Retinoic acid was threefold more potent than all-trans-retinoic acid in assays to inhibit growth and to induce differentiation of HL-60 cells. The activity of 9, 13-di-cis-retinoic acid was as high as that of all-trans-retinoic acid. Both 9-cis-retinoic acid and 9, 13-di-cis-retinoic acid acted additively with all-trans-retinc is acid on HL-60 cells. Both 9-cis-retinoic acid and 9, 13-di-cis-retinoic acid acted synergetirally with 1α, 25-dihydroxyvitamin D3 to inhibit HL-60 cell proliferation. Thyroid hormone (T3) did not affect the action of the retinoids on HL-60 cells.
- 日本学士院の論文
著者
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Matsui Masanao
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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SUZUKI Takakazu
Department of Clinical Genetics (II), The Tokyo Metropolitan Institute fo Medical Science
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MURAYAMA Akira
Department of Agriculture, The University of Tokyo
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MURAYAMA Akira
Department of Clinical Genetics, The Tokyo Metropolitan Institute of Medical Science
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SUZUKI Takakazu
Department of Clinical Genetics, The Tokyo Metropolitan Institute of Medical Science
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