Analyses of Beta-1 Syntrophin, Syndecan 2 and Gem GTPase as Candidates for Chicken Muscular Dystrophy

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概要

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• Despite intensive studies of muscular dystrophy of chicken, the responsible gene has not yet been identified. Our recent studies mapped the genetic locus for abnormal muscle (AM) of chicken with muscular dystrophy to chromosome 2q using the Kobe University (KU) resource family, and revealed the chromosome region where the AM gene is located has conserved synteny to human chromosome 8q11-24.3, where the beta-1 syntrophin (SNTB1), syndecan 2 (SDC2) and Gem GTPase (GEM) genes are located. It is reasonable to assume those genes might be candidates for the AM gene. In this study, we cloned and sequenced the chicken SNTB1, SDC2 and GEM genes, and identified sequence polymorphisms between parents of the resource family. The polymorphisms were genotyped to place these genes on the chicken linkage map. The AM gene of chromosome 2q was mapped 130 cM from the distal end, and closely linked to calbindin 1 (CALB1). SNTB1 and SDC2 genes were mapped 88.5 cM distal and 27.6 cM distal from the AM gene, while the GEM gene was mapped 18.5 cM distal from the AM gene and 9.1 cM proximal from SDC2. Orthologues of SNTB1, SDC2 and GEM were syntenic to human chromosome 8q. SNTB1, SDC2 and GEM did not correspond to the AM gene locus, suggesting it is unlikely they are related to chicken muscular dystrophy. However, this result also suggests that the genes located in the proximal region of the CALB1 gene on human chromosome 8q are possible candidates for this disease.

• 社団法人　日本実験動物学会の論文
• 2003-10-01

著者

• KIKUCHI Tateki

  Department of Animal Models for Human Disease, National Institute of Neuroscience, NCNP

• MANNEN Hideyuki

  Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University

• Kikuchi Tateki

  Department Of Animal Husbandry Faculty Of Agriculture Tohoku University

• Kikuchi Tateki

  Department Of Animal Models For Human Disease National Institute Of Neuroscience Ncnp

• YOSHIZAWA Kanako

  Graduate School of Science and Technology, Kobe University

• MIZUTANI Makoto

  Nippon Institute for Biological Science, Laboratory Animal Research Station

• Mannen Hideyuki

  Laboratory Of Animal Breeding And Genetics Faculty Of Agriculture Kobe University

• Yoshizawa Kanako

  Graduate School Of Science And Technology Kobe University

• INABA Kyoko

  Graduate School of Science and Technology, Kobe University

• TSUJI Soichi

  Laboratory of Animal Breeding and Genetics, Faculty of Agriculture, Kobe University

• Tsuji S

  Laboratory Of Animal Breeding And Genetics Faculty Of Agriculture Kobe University

• Tsuji Shuichi

  Future Science And Technology Joint Research Center Institute Of Glycotechnology Tokai University

• Takashima Shou

  Cellular Biochemistry Laboratory Riken

• Mannen H

  Kobe Univ. Kobe‐shi Jpn

• Mizutani M

  Nippon Institute Of Biological Science

• Inaba Kyoko

  Graduate School Of Science And Technology Kobe University

• Tsuji Soichi

  Laboratory Of Animal Breeding And Genetics Faculty Of Agriculture Kobe University

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