Role of CD4^+ and CD8^+ T Cells in Mouse Hepatitis Virus Infection in Mice
スポンサーリンク
概要
- 論文の詳細を見る
Viral growth and histopathological changes in the liver after intraperitoneal infection with mouse hepatitis virus, strain JHM were compared among normal C57BL/6 mice, those depleted of CD4+ T cells, CD8+ T cells and both T cell subsets. Viral growth in mice depleted of CD4+ T cells increased slightly, but pathological changes resembled those in normal mice. In contrast, the hepatitis was exacerbated in mice depleted of CD8+ T cells and those depleted of both T cell subsets. These results suggest that CD8+ T cells play a key role although both T cell subsets are involved in protection against mouse hepatitis virus infection in mice.
- 社団法人 日本実験動物学会の論文
著者
-
KYUWA Shigeru
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
-
Machii K
National Inst. Of Health Sci. Tokyo
-
Machii Kenji
Department Of Veterinary Public Health National Institute Of Public Health
-
Kyuwa Shigeru
Department Of Animal Pathology Institute Of Medical Science University Of Tokyo
-
SHIBATA Shinwa
Laboratory of Veterinary Pathology, Faculty of Agriculture, University of Tokyo
-
Shibata Shinwa
Laboratory Of Veterinary Pathology Faculty Of Agriculture University Of Tokyo
関連論文
- マウスノロウイルスS7株に対する特異抗体を検出するための間接ELISA法および間接蛍光抗体法
- ストレプトゾトシン誘発糖尿病APAハムスターの大動脈における小胞体ストレス
- Astroglial responses against Aβ initially occur in cerebral primary cortical cultures : species differences between rat and cynomolgus monkey
- Immunohistochemical Analysis of Protein Gene Product 9.5, a Ubiquitin Carboxyl-terminal Hydrolase, during Placental and Embryonic Development in the Mouse
- Protective Effects of Probucol Treatment on Pancreatic β-cell Function of SZ-induced Diabetic APA Hamsters
- Characterization of the Testis in Congenitally Ubiquitin Carboxy-Terminal Hydrolase-1 (Uch-L1) Defective (gad) Mice
- Changes in mRNA Expression in Mouse Postnatal Cochlea by Differential Display Method
- The Effect of Probucol on Atherosclerosis in Streptozotocin-Induced Diabetic-Hyperlipidemic APA Hamsters in Different Stages of Atherosclerosis
- Histopathological Studies of Aortic Dissection in Streptozotocin-Induced Diabetic APA Hamsters
- Presenilin-2 in the cynomolgus monkey brain : investigation of age-related changes
- Comparative Study on Toxicokinetics of Bisphenol A in F344 Rats, Monkeys (Macaca fascicularis), and Chimpanzees (Pan troglodytes)
- Molecular Evolution Inferred from Immunological Cross-reactivity of Immunoglobulin G among Chiroptera and Closely Related Species
- Analysis of cDNA Coding MHC Class II β Chain of The Chimpanzee (Pan troglodytes)
- Asparagine-linked Glycosylation of the Rat Leukemia Inhibitory Factor Expressed by Simian COS7 Cells
- Replication of Murine Coronaviruses in Mouse Embryonic Stem Cell Lines in vitro
- Characterization of Embryonic Stem-Like Cell Lines Derived from Embryoid Bodies
- Role of CD4^+ and CD8^+ T Cells in Mouse Hepatitis Virus Infection in Mice
- Sendai Virus Vecto-mediated Gene Transfer of Glial Cell Line-Derived Nertotrophic Factor Prevents Delayed Neuronal Death after Transient Global Ischemia in Gerbils
- Changes in mRNA Expression in Mouse Postnatal Cochlea by Differential Display Method
- Evaluation of Enzyme-Linked Immunosorbent Assay (ELISA) Kit for Paralytic Shellfish Poisoning Toxins
- マウスノロウイルスS7株に対する特異抗体を検出するための間接ELISA法および間接蛍光抗体法
- Molecular Cloning and Expression Analysis of the Bat Toll-Like Receptor 3,7, and 9
- Molecular Cloning and Sequencing of the cDNAs Encoding the Bat Interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12p40, and Tumor Necrosis Factor-Alpha
- Direct Experimental Occlusion of the Distal Middle Cerebral Artery Induces High Reproducibility of Brain Ischemia in Mice
- Natural Killer T Cells in Adipose Tissue Are Activated in Lean Mice