Crescentic Glomerulonephritis in a Polar Bear (Ursus maritimus)

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概要

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• Spontaneous crescentic glomerulonephritis (CrGN) in animals has only been reported in dog and sheep. We report the pathological features of CrGN in a 17-year-old male polar bear that died due to renal failure. Histologically, the lesions were characterized by fibrocellular crescents, adhesion between Bowman's capsule and the glomerular capillary tuft and an increase in the mesangial matrix in glomeruli. The proliferating cells in the crescent were partly immunopositive for cytokeratin and intensely positive for vimentin, WT-1 and α-smooth muscle actin, suggesting they originated from parietal epithelial cells. Ultrastructually, thickening of the glomerular basement membrane and loss of epithelial cell foot processes were observed with electron-dense deposits.

著者

• Une Yumi

  Laboratory Of Veterinary Pathology Azabu University

• KUDO Tomoo

  Laboratory of Veterinary Pathology, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan

• BABA Hiroshi

  Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252–5201, Japan

• MAKINO Yoshinori

  Hamamatsu Zoo, Hamamatsu, Shizuoka 431–1209, Japan

• MOCHIZUKI Yasumasa

  Hamamatsu Zoo, Hamamatsu, Shizuoka 431–1209, Japan

• TAKAGI Takayo

  Hamamatsu Zoo, Hamamatsu, Shizuoka 431–1209, Japan

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