EFFECT OF TEMPERATURE ON THE EREQUENCY OF CHROMOSOME ABERRATIONS AND MICRONUCLEI IN CULTURED CHINESE HAMSTER CELLS
スポンサーリンク
概要
- 論文の詳細を見る
We previously reported that both hyperthermia and hypothermia induced micronuclei in mouse bone marrow cells(Asanami and Shimono, 1997a, 1997b, 1999). To investigate the effects of temperature on chromosome aberration in vitro, we conducted chromosome aberration and micronucleus tests under hyper- and hypothermic conditions using Chinese hamster lung(CHL)cells. In the chromosome aberration test, we observed positive responses at 40℃ and 41℃ for 24 hr, and at 42℃ for 6 hr and over. In the micronucleus test, we observed positive responses at 31℃, 33℃, and 40℃ for 24 hr, and at 42℃ for 2 hr. The results suggest that in CHL cells, hypothermic conditions can induce micronuclei while hyperthermic conditions can induce both chromosome aberrations and micronuclei.
- 日本トキシコロジー学会の論文
- 2001-12-21
著者
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KANEDA Shinya
Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.
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Shimono Kazuyuki
Naruto Research Institute Otsuka Pharmaceutical Factory Inc.
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ASANAMI Shougo
Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.
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Kaneda Shinya
Naruto Research Institute Otsuka Pharmaceutical Factory Inc.
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Asanami Shougo
Naruto Research Institute Otsuka Pharmaceutical Factory Inc.
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