Metabolism of Terephthalic Acid. III. Absorption of Terephthalic Acid from Gastrointestinal Tract and Detection of Its Metabolites.
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概要
- 論文の詳細を見る
The absorption of terephthalic acid (TPA) from gastrointestinal tract and its metabolites in urine were studied with radioactive TPA (carboxyl-^<14>C compound). Terephthalic acid was absorbed mainly from stomach and small intestine and partly from caecum and large intestine. The administered TPA was excreted almost quantitatively in urine within 24 hr. after the administration, and carbon dioxide as the cleavaged product was not found in the expired air. Examinations by thin-layer chromatography and autoradiography technique failed to detect any metabolite in urine. It was concluded that the administered TPA is not metabolized in body and almost all of it is excreted intact in urine.
- 公益社団法人日本薬学会の論文
- 1967-12-25
著者
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星昭 夫
国立がんセンター研究所薬効試験部
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榑谷 和男
Pharmacology Division, National Cancer Center Research Institute
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星 昭夫
Pharmacology Division, National Cancer Center Research Institute
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榑谷 和男
Pharmacology Division National Cancer Center Research Institute
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槫谷 和男
Pharmacology Division National Cancer Center Research Institute
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