Neurotropic and Psychotropic Agents. V. An Improved Synthesis of 7-Chloro-5-(2-chlorophenyl)-2-(2-dimethylaminoethylthio)-3H-1,4-benzodiazepine and Related Compounds
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概要
- 論文の詳細を見る
An improved method for the synthesis of 7-chloro-5-(2-chlorophenyl)-2-(2-dimethylaminoethylthio)-3H-1,4-benzodiazepine (IIa) and related compounds is described. IIa was obtained in 75.1% yield by the reaction of the 1,4-benzodiazepin-2-one (Ia) with 2-dimethylaminoethanethiol in the presence of titanium tetracbloride ; a small amount of 7-chloro-5-(2-chlorophenyl)-2-dimethylamino-3H-1,4-benzodiazepine (III) was obtained as a byproduct. A mechanistic interpretation of the formation of III is presented.
- 社団法人日本薬学会の論文
- 1982-04-25
著者
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松尾 昌昭
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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植田 育男
Institute Of Scientific And Industrial Reseach Osaka University
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植田 育男
Central Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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谷口 清
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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松尾 昌昭
Central Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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谷口 清
Central Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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渡辺 隆夫
Central Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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松尾 昌昭
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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渡辺 隆夫
Central Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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