Total Synthesis of Pyrrolnitrin. V. Synthesis of Pyrrolnitrin and Its Analogues. (1)
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概要
- 論文の詳細を見る
The structure for pyrrolnitrin by chemical degradation was established. Pyrrolnitrin, 3-(2-nitro-3-chlorophenyl)-4-chloropyrrole (XIIIa), and several 3-aryl-4-chloropyrroles (XIII) were derived from ethyl 3-aryl-5-trichloromethyl-4-chloro-2-pyrrolecarboxylates (VII) via 3-aryl-4-chloro-2,5-pyrroledicarboxylic acids (X). VII could be obtained by exhaustive chlorination of three kinds of starting materials, ethyl 3-aryl-5-methyl-2-pyrrolecarboxylates (I), 2-ethoxycarbonyl-3-aryl-5-methyl-4-pyrrolecarboxylic acids (III) and ethyl 3-(2-nitro-3-chlorophenyl)-4-chloro-5-methyl-2-pyrrolecarboxylate (IVa).
- 社団法人日本薬学会の論文
- 1969-03-25
著者
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海尾 澄則
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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刈米 和夫
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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田中 邦彦
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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植田 育男
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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森本 行洋
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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田中 邦彦
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
刈米 和夫
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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森本 行洋
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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植田 育男
Central Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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海尾 澄則
Fujisawa Pharmaceutical Co. Ltd.
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