Structure-Activity Studies of Pyrrolnitrin Analogues
スポンサーリンク
概要
- 論文の詳細を見る
A number of de-chloro and de-nitro derivatives of pyrrolnitrin and the isomers as to the positions of the substituents were prepared and their antimicrobial activities were evaluated. Among the homologues having a nitro group, pyrrolnitrin has shown the strongest activity, in which the nitro group is suffered from steric hindrance. 2-Methyl-4-(2-nitro-3-chlorophenyl) pyrrole (10a) was also as effective as pyrrolnitrin. On the other hand, the de-nitro derivatives, 3-chloro-4-(3-chlorophenyl) pyrrole (8o), 3-chloro-4-(3-bromophenyl) pyrrole (8g) and 3-chloro-4-(3-trifluoromethyl) pyrrole (8t), showed stronger antimicrobial activities and broader spectra.
- 社団法人日本薬学会の論文
- 1970-07-25
著者
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海尾 澄則
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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刈米 和夫
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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田中 邦彦
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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中村 仁司
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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岸本 禎二
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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田中 邦彦
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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刈米 和夫
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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中村 仁司
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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岸本 禎二
Central Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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海尾 澄則
Fujisawa Pharmaceutical Co. Ltd.
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西田 実
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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西田 実
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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