Total Synthesis of Pyrrolnitrin. I. Synthesis of 3-Arylpyrrole Derivatives by Knorr's Condensation
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概要
- 論文の詳細を見る
Alkyl 3-aryl-5-methyl-4-pyrrolecarboxylate (IIIa-j) and alkyl 2,5-dimethyl-3-aryl-4-pyrrolecarboxylate (IIIk-m), two kinds of key intermediates for synthesizing pyrrolnitrin (I), were obtained from 2-aminoacetophenones (IV) and alkyl acetoacetate by Knorr's pyrrole synthesis. The mechanism of the pyrrole ringclosure of the above compounds was proposed since alkyl 3-substituted benzoylmethylaminocrotonates (VIII) could be isolated as intermediates presumably because of their difficult cyclization to the corresponding pyrroles ; for which the infrared spectra of nitro and carbonyl group of VIII were discussed.
- 社団法人日本薬学会の論文
- 1969-03-25
著者
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海尾 澄則
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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刈米 和夫
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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田中 邦彦
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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中村 仁司
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
田中 邦彦
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
刈米 和夫
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
中村 仁司
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
海尾 澄則
Fujisawa Pharmaceutical Co. Ltd.
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