Total Synthesis of Pyrrolnitrin. II. Synthesis of Ethyl 3-Aryl-5-methyl-2-pyrrolecarboxylate. (1)

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概要

• 論文の詳細を見る

• Ethyl 3-aryl-5-methyl-2-pyrrolecarboxylate (XXIII), a desirable intermediate for chlorination to prepare pyrrolnitrin, was derived from ethyl 3-aryl-5-methyl-4-pyrrolecarboxylate (I) by following two routes. At first, it was undertaken to introduce a second ester group to the 2-position of I before the first ester group at the 4-position of I was eliminated. Then the first ester group was hydrolysed selectively and the resulting carboxyl group was removed by decarboxylation. Secondly, the ester group of I was eliminated at first, affording 3-aryl-5-methylpyrrole (XIV). Introduction of an ester group to 2-position of XIV was carried out successively by two methods via a cyano group or a carbonyl chloride group.

• 社団法人日本薬学会の論文
• 1969-03-25

著者

• 中野 浩

  藤沢薬工研究所

• 中野 浩

  Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• 海尾 澄則

  Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• 刈米 和夫

  Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• 田中 邦彦

  Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• 植田 育男

  Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• 中村 仁司

  Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• 田中 邦彦

  Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• 刈米 和夫

  Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• 中村 仁司

  Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• 植田 育男

  Central Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• 海尾 澄則

  Fujisawa Pharmaceutical Co. Ltd.

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