Total Synthesis of Pyrrolnitrin. III. Synthesis of Ethyl 3-Aryl-5-methyl-2-pyrrolecarboxylate. (2)
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概要
- 論文の詳細を見る
Cyclization of diethyl N-[1-methyl-3-(2-nitro-3- chlorophenyl)-3-oxopropylidene]-aminomalonate (XV) with polyphosphoric acid ethyl ester (PPE) gave ethyl 3-(2-nitro-3-chlorophenyl-5-methyl-2-pyrrolecarboxylate (XVI) in good yield. In such reaction, diethyl 3-(3-chlorophenyl)-5-methyl-2,2-(2H)-pyrroledicarboxylate (XX) was obtained easily by ring-close of diethyl N-[1-methyl-3-(3-chlorophenyl)-3-oxopropylidene] aminomalonate (XVIII) with PPE. It may be concluded from this result that ethyl 3-aryl-5-methyl-2-pyrrolecarboxylate was prepared via the 2H-pyrrole compound from the corresponding enamine.
- 社団法人日本薬学会の論文
- 1969-03-25
著者
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海尾 澄則
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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刈米 和夫
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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田中 邦彦
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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岸本 禎二
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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田中 邦彦
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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刈米 和夫
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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岸本 禎二
Central Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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海尾 澄則
Fujisawa Pharmaceutical Co. Ltd.
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