Total Synthesis of Pyrrolnitrin. X. Synthesis of Pyrrolnitrin. (2)
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概要
- 論文の詳細を見る
Conversion of 2,5-disubstituted-3-arylpyrrole (II) to pyrrolnitrin (Ia) and the related compounds (I) was investigated. II was transformed by chlorination followed by hydrolysis and oxidation to 3-aryl-4-chloro-2,5-pyrroledicarboxylic acids (IV), which were decarboxylated to I in sulfuric acid. Dialkyl 3-aryl-4-chloro-2,5-pyrroledicarboxylate (XI), alkyl β-aryl-4-chloropyrrolecarboxylates and halfesters of IV afforded Ia directly, when heated in sulfuric acid.
- 社団法人日本薬学会の論文
- 1969-03-25
著者
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海尾 澄則
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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刈米 和夫
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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田中 邦彦
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
田中 邦彦
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
刈米 和夫
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
海尾 澄則
Fujisawa Pharmaceutical Co. Ltd.
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