Studies on Insecticides. V. Synthesis of 2-Piperidone Derivatives.
スポンサーリンク
概要
- 論文の詳細を見る
Hydrogenation of 2 (1H)-pyridones was carried out in methanol over Raney nickel at 120 atm. and 200〜240°and gave 2-piperidone derivatives. When the reduction temperature was raised to 280°, hydrogenation of carbonyl group took place, followed by N-methylation of the resulting piperidine derivative was observed. On the other hand, when the reaction temperature was kept below 180°, the starting material was recovered unchanged. By the action of acetic anhydride on 4-ethylpyridine 1-oxide, 4-(1-hydroxyethyl) pyridine and 4-ethyl-3-hydroxypyridine were obtained, while 4-methoxycarbonylpyridine 1-oxide gave 4-methoxycarbonyl-2 (1H)-pyridone.
- 社団法人日本薬学会の論文
- 1960-12-25
著者
-
刈米 和夫
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
刈米 和夫
Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
高橋 西蔵
Faculty of Pharmacy, Kyoto University
-
高橋 西蔵
Faculty Of Pharmacy Kyoto University
関連論文
- Total Synthesis of Pyrrolnitrin. II. Synthesis of Ethyl 3-Aryl-5-methyl-2-pyrrolecarboxylate. (1)
- Pyrrolnitrinの全合成
- Total Synthesis of Pyrrolnitrin. V. Synthesis of Pyrrolnitrin and Its Analogues. (1)
- The Structures of Tomaymycin and Oxotomaymycin
- Studies on Insecticides. VI. Synthesis of Proline Derivatives.
- Studies on Insecticides. V. Synthesis of 2-Piperidone Derivatives.
- Structure-Activity Studies of Pyrrolnitrin Analogues
- Total Synthesis of Pyrrolnitrin. X. Synthesis of Pyrrolnitrin. (2)
- Total Synthesis of Pyrrolnitrin. IX. Synthesis of Dialkyl 3-Aryl-2,5-pyrroledicarboxylates and Alkyl β-Aryl-5-methyl-2-pyrrolecarboxylates
- Total Synthesis of Pyrrolnitrin. VIII. A New Method of Pyrrole Ringclosure using Aminoacetal
- Total Synthesis of Pyrrolnitrin. VII. Synthesis of 2,5-Dimethyl-3-arylpyrrole
- Total Synthesis of Pyrrolnitrin. VI. Synthesis of Nitro-chloro-2-aminoacetophenones and 1-Aryl-1,3-butanediones
- Total Synthesis of Pyrrolnitrin. IV. Synthesis of Ethyl 3-Aryl-5-methyl-2-pyrrolecarboxylate. (3)
- Total Synthesis of Pyrrolnitrin. III. Synthesis of Ethyl 3-Aryl-5-methyl-2-pyrrolecarboxylate. (2)
- Total Synthesis of Pyrrolnitrin. I. Synthesis of 3-Arylpyrrole Derivatives by Knorr's Condensation