New 2-Aryliminoimidazolidines. I. Synthesis and Antihypertensive Properties of 2-(2-Phenoxyphenylimino) imidazolidines and Related Compounds
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概要
- 論文の詳細を見る
2-(2-Phenoxyphenylimino) imidazolidine and related compounds (IV and XII) were synthesized and evaluated for hypotensive activity in rats. Most of the 2-aryliminoimidazolidines (IV) were synthesized via the aniline derivatives (VI) by two different methods. Some imidazolidines (IV) were found to be significantly active, with 2-(5-chloro-2-phenoxyphenylimino) imidazolidine (IV-19) being more active than prazosin, the reference compound. The mechanism of action of IV-9 may involve the blockade of peripheral α-adrenergic receptors. This paper describes the synthesis, pharmacology, and structure-activity relationships of the 2-(2-phenoxyphenylimino) imidazolidines.
- 社団法人日本薬学会の論文
- 1985-10-25
著者
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松尾 昌昭
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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植田 育男
Institute Of Scientific And Industrial Reseach Osaka University
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植田 育男
Central Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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谷口 清
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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桂 洋介
New Drung Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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松尾 昌昭
Central Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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谷口 清
Central Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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桂 洋介
Central Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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上谷 利治
Central Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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桂 洋介
New Drung Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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松尾 昌昭
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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上谷 利治
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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