Studies on Antiulcer Drugs. II. Synthesis and Antiulcer Activities of Imidazo[1,2-a]pyridinyl-2-alkylaminobenzoxazoles and 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridinyl Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
A series of imidazo[1,2-a]pyridinylbenzoxazoles (4) and 5,6,7,8-tetrahydroimidazo[1,2-a]pyridinylbenzoxazoles (5) were synthesized and tested for anti-stress ulcer activity in rats. Several compounds were found to be more active than the reference compounds, sucralfate, cimetidine and ranitidine. Some of them exhibited potent protective activity against ethanol-induced gastric lesion. The synthesis and structure-activity relationships of these compounds are discussed.
- 公益社団法人日本薬学会の論文
- 1992-02-25
著者
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桂 洋介
New Drung Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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井上 善一
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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西野 重孝
New Drug Research Laboratories
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友井 正明
Product Development Laboratories
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桂 洋介
New Drung Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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井上 善一
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd
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西野 重孝
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Nishino S
Fujisawa Pharmaceutical Co. Ltd. Osaka Jpn
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友井 正明
Product Development Laboratories Fujisawa Pharmaceutical Co. Ltd.
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