Studies on Cerebral Protective Agents. II. Novel 4-Arylphrimidine Derivatives with Anti-anoxic and Anti-lipid Peroxidation Activities. (2)
スポンサーリンク
概要
- 論文の詳細を見る
In a search for were cerebral protective agents with anti-anoxic (AA) and anti-lipid peroxidation (ALP) activities, a series of 4-arylpyrimidines, bearing an amino moiety in the C-5 position of the pyrimidine nucleus, was synthesized and tested for AA and ALP activities. Among them, 6-methyl-5-(4-methylpiperazin-1-ylcarbonyl)-4-(3-nitrophenyl)-2-phenylprimidine (41,FK360) was most effective on both assays and on arachidonate-induced cerebral edema in rats.Structure-acivity relationships in regard to AA activity of this series of compounds are also discussed.
- 公益社団法人日本薬学会の論文
- 1992-09-25
著者
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久野 敦司
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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酒井 裕義
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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勝田 清貴
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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杉山 良恵
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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勝田 清貴
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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酒井 裕義
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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杉山 良恵
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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久野 敦司
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Sakai H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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