Studies on β-Lactam Antibiotics. XIV. : Synthesis and Biological Activity of the (E)-Isomer of FK027
スポンサーリンク
概要
- 論文の詳細を見る
The (E)-isomer (11) of FK027 was synthesized by two methods. The effect of the configuration of the oxime in the 7-acyl side chain of FK027 (1) on the antimicrobial activity and oral absorbability in rats was investigated. Both FK027 (1) and its (E)-isomer (11) showed appreciable oral absorbability regardless of the configuration of the oxime.
- 公益社団法人日本薬学会の論文
- 1986-08-25
著者
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高谷 隆男
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd
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高谷 隆男
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Kawabata K
Kobe Women's Coll. Pharmacy Kobe Jpn
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Kawabata Kohji
Central Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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宮井 健二
Central Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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高杉 寿
Central Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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高谷 隆男
Central Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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