Studies on Antiulcer Drugs. III. Synthesis and Antiulcer Activities of Imidazo[1,2-a]pyridinylethyl-benzoxazoles and Related Compounds. A Novel Class of Histamine H_2-Receptor Antagonists
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概要
- 論文の詳細を見る
A series of imidazo[1,2-a]pyridinylalkylbenzoxazole derivatives was synthesized and tested for histamine H_2-receptor antagonist, gastric antisecretory and antiulcer activities. Some of 2-amino-6-[2-(imidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole derivatives were found to have good pharmacological activities. Among them, 2-amino-6-[2-(7-methoxy-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (II-11) and 2-acetamido-6-[2-(7-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (II-38) showed potent antisecretory and cytoprotective activity. The structure-activity relationships of these compounds are discussed.
- 社団法人日本薬学会の論文
- 1992-06-25
著者
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伊藤 立信
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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桂 洋介
New Drung Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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井上 善一
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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西野 重孝
New Drug Research Laboratories
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友井 正明
Product Development Laboratories
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桂 洋介
New Drung Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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井上 善一
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd
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西野 重孝
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Nishino S
Fujisawa Pharmaceutical Co. Ltd. Osaka Jpn
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友井 正明
Product Development Laboratories Fujisawa Pharmaceutical Co. Ltd.
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