Studies on Antiulcer Drugs. I. Synthesis and Antiuler Activities of Imidazo[1,2-a]pyridinyl-2-oxobenzoxazolidines-3-oxo-2H-1,4-benzoxazines and Related Compounds
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概要
- 論文の詳細を見る
A series of imidazo[1,2-α]pyridinyl-2-oxobenzoxazolidines (4a-i), -3-oxo-2H-1,4-benzoxazines (5a-q), their thio-analogues (4j-p and 5r-t) and 5,6,7,8-tetrahydroimidazo[1,2-α]pyridinyl derivatives (8 and 9) were synthesized and tested for anti-stress ulcer activity in rats. Several compounds were found to be more active than the reference compounds, zolimidine, cimetidine and sucralfate. Among them, compound 4e, 5i and 5l also exhibited potent protective activity against ethanol-induced gastric lesion. The synthesis and structure-activity relationships of these compounds are discussed.
- 公益社団法人日本薬学会の論文
- 1991-11-25
著者
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桂 洋介
New Drung Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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西野 重孝
New Drug Research Laboratories
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桂 洋介
New Drung Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd
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西野 重孝
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Nishino S
Fujisawa Pharmaceutical Co. Ltd. Osaka Jpn
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