Studies on antiulcer Drugs. VI. 4-Furyl-2-guanidinothiazoles and Related Compounds as Potent Histamine H_2-Receptor Antagonists
スポンサーリンク
概要
- 論文の詳細を見る
A series of 4-furyl-2-guanidinothiazole derivatives and related compounds were synthesized and evaluated for histamine H_2-receptor antagonist and gastric acid antisecretory activities. Among them, compounds I-17,I-48 and I-49 showed high activities in these tests. In addition, compound I-17 possessed potent inhibitory activities on each of the gastric ulcers induced by stress, ethanol and HCl-aspirin. On the other hand, compound I-48 demonstrated antimicrobial activity against Helicobacter Pylori and the potenvy was faer stronger than that of clinically used H_2-antaginists. Some structure-activity relationships are discussed.
- 社団法人日本薬学会の論文
- 1992-09-25
著者
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伊藤 立信
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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桂 洋介
New Drung Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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井上 善一
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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冨士 哲男
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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石川 弘文
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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桂 洋介
New Drung Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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石川 弘文
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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井上 善一
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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冨士 哲男
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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