Studies on Antiinflammatory Agents. I. Synthesis and Pharmacological Properties of 2'-Phenoxy-methanesulfonanilide Derivatives
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概要
- 論文の詳細を見る
Various 2'-phenoxymethanesulfonanilide derivatives were synthesized and evaluated for antiinflammatory and analgesic activities. Some compounds bearing an electron-attracting substituent at the 4'-position strongly inhibited adjuvant-induced arthritis in rats and acetic acid-induced writhing syndrome in mice without causing gastro-intestinal irritation. Among them, 4'-cyano-(FK867) and 4'-acetyl-(FK3311) 2'-(2,4-difluorophenoxy)methanesulfonanilides were selected as the candidates for further development.
- 社団法人日本薬学会の論文
- 1992-09-25
著者
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中村 克哉
藤沢薬品工業株式会社 新薬研究所
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松尾 昌昭
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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辻 喜良
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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松尾 昌昭
藤沢薬品工業株式会社 新薬研究所
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中村 克哉
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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小西 信清
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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奥村 広之
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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小西 信清
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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松尾 昌昭
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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奥村 広之
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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