Micelle/Water Partition Properties of Phenols Determined by Liquid Chromatographic Method. Proposal for Versatile Measure of Hydrophobicity
スポンサーリンク
概要
- 論文の詳細を見る
Partition properties have been determined for 28 monosubstituted phenols in the sodium dodecylsulfate (SDS)/water system by micellar liquid chromtography (MLC), offering a useful and versatile method to estimate the hydrophobicity of compounds. The enthalpy and entropy terms of partition have also been determined from variable temperature experiments on MLC and are interpreted by such factors as molecular size and hydrogen-bond ability of the solute. The π constants (π, π_H and π_S) are determined from the experimental partition properties and applied to quantitative structure-activity relationships (QSAR) analysis, and their versatility supported.
- 社団法人日本薬学会の論文
- 1995-03-15
著者
-
藤原 英明
Faculty Of Pharmaceutical Sciences Osaka University
-
植田 育男
Institute Of Scientific And Industrial Reseach Osaka University
-
中村 克彦
Faculty of Pharmaceutical Sciences, Osaka University
-
林 一也
Faculty of Pharmaceutical Sciences, Osaka University
-
林 一也
Faculty Of Pharmaceutical Sciences Osaka University
-
中村 克彦
Faculty Of Pharmaceutical Sciences Osaka University
関連論文
- Micelle/Water Partition Properties of Phenols Determined by Liquid Chromatographic Method. Proposal for Versatile Measure of Hydrophobicity
- Thermochemical Aspects of Partition. Quantitative Structure Activity Relationships of Benzyldimethylalkylammonium Chlorides
- Synthesis and Structures of 6-Aryl-1,5-dimethoxycarbonyl-2-methyl-4-morpholino-1,3-cyclohexadienes and Related Compounds
- New 2-Aryliminoimidazolidines. II. Synthesis and Antihypertensive Activity of 2-(Biphenylimino)-imidazolidines
- New 2-Aryliminoimidazolidines. I. Synthesis and Antihypertensive Properties of 2-(2-Phenoxyphenylimino) imidazolidines and Related Compounds
- Neurotropic and Psychotropic Agents. VII. Synthesis and Pharmacological Properties of 2-(Alkoxyalkylamino)-3H-1,4-benzodiazepines
- Neurotropic and Psychotropic Agents. V. An Improved Synthesis of 7-Chloro-5-(2-chlorophenyl)-2-(2-dimethylaminoethylthio)-3H-1,4-benzodiazepine and Related Compounds
- Neurotropic and Psychotropic Agents. IV. Synthesis and Pharmacological Properties of 7-Chloro-5-(2-chlorophenyl)-2-(2-dimethylaminoethylthio)-3H-1,4-benzodiazepine and Related Compounds
- Design, Synthesis and Antiinflammatory Activity of a New Indomethacin Ester. 2-[N-[3-{3-(Piperidinomethyl)phenoxy}propyl]carbamoylmethylthio]ethyl 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate
- Antiulcer Agents. III. Synthesis and Antiulcer Activity of N-[3-(3-Piperidinomethylphenoxy)propyl]pentacyclo[4.2.0.0^.0^.0^]-octane Carboxamides and Related Compounds
- Reaction of 4-(N, N-Dimethylamino)-2-phenyl-2-(2-pyridyl)butanenitrile and Related Compounds with Ethyl Chloroformate; Formation of Indolizinium and Quinolizinium Chlorides
- Smiles Rearrangement of 2-(1-Methyl-1H-tetrazol-5-ylthio)acetamides and Their Sulfonyl Derivatives
- Antiulcer Agents. II. Synthesis and Gastric Acid Antisecretory Activity of N-[3-{3-(Piperidinomethyl)phenoxy}propyl]-4-(1-methyl-1H-tetrazol-5-ylthio)butanamide and Related Compounds
- Synthesis and Pharmacological Properties of N-[3-{3-(1-Piperidinylmethyl)phenoxy}propyl]-2-(2-hydroxyethylthio)acetamide and Related Compounds as Antiulcer Agents.I
- Synthesis of 7β-[(Z)-2-(2-Amimo-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic Acid (Ceftizoxime), a New Semisynthetic Cephalsporin Antibiotic. I. : An Improved Method for the Preparation of 7-Amino-3-methylene- and 7-amino-3-hydroxycepham-4-
- Revised Interpretations of Electronic Substituent Constants Using Electron Number Analysis and Molecular Electrostatic Potential
- Practical Synthesis of T-3761,(S)-10-(1-Aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
- Development of an Applications for a Simulater of Intermolecular Potentials. III. Development of SIMP/II and SIMP/D and Their Application
- Thermochemical Aspects of Partition of Methyl- and Halogen-Substituted Alcohols in 1-Octanol/Water and a Novel Regression Analysis of Alcohol Toxicities
- Nuclear Magnetic Resonance Relaxation Study of Strychnine in Solution. Molecular Dynamics Models for the Interpretation of ^C T_1 Data and Relaxation Mechanisms of the Quaternary Carbons
- Factor Analysis of the Solute-Stationary Phase Interactions in Gas-Liquid Chromatography Using the Oblique Procrastes Transformation
- THE GASEOUS STANDARD ENTROPY S°_ (g) OF THE 3RD LAW OF THERMODYNAMICS CAN BE ESTIMATED FROM GAS-CHROMATOGRAPHIC RETENTION DATA
- Nuclear Magnetic Resonance Studies of Acid-Base Association in Solution. II. Association between Ketones and Tris (dipivaloylmethanato) europium
- Studies on the Proton Magnetic Resonance Spectra of Aliphatic Systems. VIII. Complex Shift and Equilibrium Constant of Aliphatic Alcohol-Tris (dipivalomethanato) europium Complex in Solution
- Studies on the Proton Magnetic Resonance Spectra of Aromatic Systems. XXI. Discussions on Stoichiometry, Equilibrium and Infinite Concentration Shift of Pyridine Base-Tris (dipivalometh-anato) europium Eu (DPM)_3 Complex in Solution