Synthetic Cephalosporins. VI. : Synthesis and Antibacterial Activity of 7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(1-carboxy-1-methyl)ethoxyiminoacetamido]-3-(3-hydroxy-4-pyridon-1-yl)methyl-3-cephem-4-carboxylic Acid and Related Compounds

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概要

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• Synthesis and antibacterial activity of 7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methyl)ethoxyiminoacetamido]-3-(3-hydroxy-4-pyridon-1-yl)-3-cephem-4-carboxylic acid (12) and its related compounds are described. Compound 12 exhibited excellent antibacterial activity against gram-negative bacteria, and its anti-pseudomonal activity was ten to fifteen times greater than that of ceftazidime.

• 公益社団法人日本薬学会の論文
• 1990-08-25

著者

• 畠中 稔

  The Institute of Scientific and Industrial Research, Osaka University

• 畠中 稔

  The Institute Of Scientific And Industrial Research Osaka University

• 坂上 健司

  Pharmaceutical Research Center, Meiji Seika Kaish , Ltd.,

• 岩松 勝義

  Pharmaceutical Research Center, Meiji Seika Kaish , Ltd.,

• 渥美 国夫

  Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.,

• 渥美 國夫

  Pharmaceutical Research Center Meiji Seika Kaisha Ltd.

• 渥美 國夫

  明治製菓株式会社 薬品総合研究所 創薬研究所

• 坂上 健司

  Pharmaceutical Research Center Meiji Seika Kaisha Ltd.

• 岩松 勝義

  Pharmaceutical Research Center Meiji Seika Kaish Ltd.

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