Inclusion Complex of a New Orally Active Cephalosporin ME1207 with β-Cyclodextrin
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概要
- 論文の詳細を見る
The structure of a 1 : 1 inclusion complex of β-cyclodextrin (β-CD) and a new orally active cephalosporin, pivaloyloxymethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate (ME1207), was estimated by nuclear magnetic resonance (NMR) analysis. The experimental results indicated that the tert-butyl moiety of ME1207 was selectively inserted into the β-CD cavity.
- 公益社団法人日本薬学会の論文
- 1992-06-25
著者
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坂上 健司
Pharmaceutical Research Center, Meiji Seika Kaish , Ltd.,
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坂上 健司
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
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田代 充
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.,
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馬込 恵子
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.,
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三木 茂子
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.,
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馬込 恵子
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
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三木 茂子
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
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田代 充
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
関連論文
- Synthetic Cephalosporins. VII. Synthesis and Antibacterial Activity of 7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(3-(3-hydroxy-4-pyridon-1-yl)-3-carboxypropoxyimino)acetamide]-(1,2,3-thiadiazol-5-yl)-thiomethyl-3-cephem-4-carboxylic Acid and Its Related Compounds
- Synthetic Cephalosporins. VI. : Synthesis and Antibacterial Activity of 7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(1-carboxy-1-methyl)ethoxyiminoacetamido]-3-(3-hydroxy-4-pyridon-1-yl)methyl-3-cephem-4-carboxylic Acid and Related Compounds
- Synthesis and Oral Activity of Pivaloyloxymethyl 7-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido]-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate (ME1207) and Its Related Compound
- Inclusion Complex of a New Orally Active Cephalosporin ME1207 with β-Cyclodextrin