The Strong Fluorescence-Quenching Effect of Ergothioneine
スポンサーリンク
概要
- 論文の詳細を見る
Ergothioneine (Erg) which possesses an imidazole-2-thione (IT) moiety had a strong quenching effect on indole fluorescence. The Stern-Volmer quenching constants (K_<SV>), which quantified its fluorescence-quenching ability were 1508 (Erg) and 517 (IT) with respect to indole at pH 5.0. Compared with the structure of IT, the K_<SV> values of ethylenethiourea (ET), which lacks a double bond between the 4 and 5 position, imidazole (IM) which lacks a sulfur atom, and mercaptoethylamine (MEA) which exhibits no thione-thiol tautomerizm were 71,14,and 18,respectively under the same instrumental conditions. According to these results, the fluorescence-quenching effect of Erg was about 20-100 times stronger than related compounds such as ET, IM, and MEA. This physico-chemical property may help clarify the biological role of Erg.
- 公益社団法人日本薬学会の論文
- 1996-01-15
著者
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Inoue T
Ohmiya Research Laboratory Fuji Yakuhin Co. Ltd
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Inoue T
Osaka University Of Pharmaceutical Sciences
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井上 輝比古
Pharmaceutical Research Department Ube Laboratory Corporate Research & Development Ube Industrie
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INOUE Takehisa
Kyoto Pharmaceutical University
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TAKESHIMA Shigeo
Kyoto Pharmaceutical University
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Takeshima S
Kyoto Pharmaceutical University
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Inoue Takao
Faculty Of Pharmaceutical Sciences Hoshi University
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