Synthetic Studies of Vitamin D Analogs. XXII.Synthesis and Antiproliferation Activity of Putative Metabolites of 1α, 25-Dihydroxy-22-oxavitamin D_3

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概要

• 論文の詳細を見る

• As putative metabolites of 1α, 25-diydroxy-22-oxavitamin D_3 (OCT), 24-hydroxylated OCT in 24(R) and 24(S) forms, 24-ketoOCT, 26-hydroxylated OCT in 25(S) and 25(R) forms, pentanorOCT and pentanor-ketoOCT were synthesized from the steroidal 20(S)-alcohol. Their antiproliferation activities towards human promyelocytic leukemia cells (HL-60 cells) are also reported. Oxidized derivatives at the C-24 position, 24-ketoOCT, 24(R)-hydroxylated OCT and 24(S)-hydroxylated OCT, showed activities comparable to or slightly weaker than that of OCT, while 26-hydroxylated OCT was less active than OCT. Truncated OCT, pentanor OCT and pentanor-ketoOCT, were inactive at 10^<-7>-10<-10> M.

• 社団法人日本薬学会の論文
• 1996-12-15

著者

• KOBAYASHI Tadashi

  Department of Physics, Aoyama Gakuin University

• 畑山 範

  長崎大学大学院医歯薬学総合研究科

• WATANABE Hiroyoshi

  Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.,

• HATAKEYAMA Susumi

  Pharmaceutical Institute, Tohoku University

• TAZUMI Kazuki

  Pharmaceutical Institute, Tohoku University

• TAKANO Seiichi

  Pharmaceutical Institute, Tohoku University

• MASUDA Sonoko

  Department of Hygienic Science, Kobe Pharmaceutical University

• OKANO Toshio

  Department of Hygienic Science, Kobe Pharmaceutical University

• KUBODERA Noboru

  Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.

• Kobayashi T

  Faculty Of Science Shinshu University

• Okano Toshio

  Department Of Hygienic Sciences Kobe Women's College Of Pharmacy

• Okano Toshio

  Department Of Hygienic Science Kobe Pharmaceutical University

• Kawanishi T

  大妻女子大学 食物学科

• Kubodera N

  Chugai Pharmaceutical Co. Ltd. Tokyo Jpn

• Watanabe H

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Kobayashi Tadashi

  Department Of Cardiology Aichi Medical University

• 畑山 範

  長崎大 大学院医歯薬学総合研究科

• Takano Seiichi

  Pharmaceutical Institute Tohoku University

• Tazumi Kazuki

  Pharmaceutical Institute Tohoku University

• Masuda S

  Kobe Pharmaceutical Univ. Kobe Jpn

• Masuda Sonoko

  Deparment Of Hygienic Sciences Kobe Pharmaceutical University:(present Address)department Of Biochem

• WATANABE Hiroyoshi

  School of Science and Engineering, Teikyo University

• Watanabe Hiroyoshi

  School Of Science And Engineering Teikyo University

• Hatakeyama Susumi

  Pharmaceutical Institute Tohoku University

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