Mechanisms of Transfer into SCID Mice Reconstituted with Tissueinfiltrating Cells from Murine Model for Sjogren's Syndrome

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概要

• 論文の詳細を見る

• To elucidate the mechanism during reconstitution of murine organ-specific autoimmune lesions developing in the salivary and lacrimal gland from MRL/lpr mice into severe combined immunodeficiency (SCID) mice, mice which received salivary gland inflammatory cells from MRL/lpr mice were analyzed for cytokine gene expressions and autoantibody production. Successful transfer of autoimmune lesions developed at 8 wk after the intraperitoneal injection of 1×10^6 cells. Flow cytometric analysis using peripheral blood mononuclear cells (PBMC) from transferred SCID mice was investigated every wk after the injection until 8 wk. Peripheral CD 4^+ T cells were detected at 2 wk or more after the injection and their number gradually increased in the periphery. RT-PCR analysis on PBMC revealed that cytokine gene expressions including IL-1β, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, IL-6, IL-10, IL-12 (p 40) were detected at 8 wk after the injection. The number of peripheral B220^+ B cells increased on PBMC during reconstitution in transferred SCID mice. Autoantibody production specific for the salivary gland was detected in sera from transferred SCID mice at 2 wk or more. These results suggest that cytokine gene stimulation and autoantibody production are involved in the development of organ-specific autoimmune lesions during reconstitution in transferred SCID mice.

• 特定非営利活動法人日本臨床口腔病理学会の論文

著者

• HAYASHI Yoshio

  Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science and 21st Centur

• Ishimaru Naozumi

  Department of Pathology, Tokushima University School of Dentistry

• Haneji Norio

  Department of Pathology, Tokushima University School of Dentistry

• Yanagi Kumiko

  Department of Pathology, Tokushima University School of Dentistry

• Hayashi Yoshio

  Department Of Pathology Tokushima University School Of Dentistry

• Haneji Norio

  Department Of Pathology Tokushima University School Of Dentistry

• Haneji Norio

  Department Of Oral Pathology School Of Dentistry Tokushima University

• Yanagi Kumiko

  Department Of Pathology Tokushima University School Of Dentistry

• Yanagi Kumiko

  Department Of Chemistry Faculty Of Science And Technology Sophia University

• NISHINO Mizuho

  Department of Pediatric Dentistry, Institute of Health Biosciences, The University of Tokushima Grad

• Nishino Mizuho

  Department Of Pediatric Dentistry Tokushima University School Of Dentistry

• Nishino Mizuho

  Department Of Pediatric Dentistry Institute Of Health Biosciences The University Of Tokushima Gradua

• Saegusa Kaoru

  Department of Pathology, Tokushima University School of Dentistry

• Saegusa Kaoru

  Department Of Pathology Tokushima University School Of Dentistry:department Of Pediatric Dentistry T

• Hayashi Yoshio

  Department Of Electrical And Electronic Engineering Kitami Institute Of Technology

• Ishimaru Naozumi

  Univ. Tokushima Graduate School Tokushima Jpn

• Ishimaru Naozumi

  Department Of Oral Molecular Pathology Institute Of Health Biosciences University Of Tokushima Gradu

• Ishimaru Naozumi

  Department Of Oral Molecular Pathology Institute Of Health Biosciences The University Of Tokushima G

• Yamaguchi H

  Department Of Oral Molecular Pathology Institute Of Health Bioscience The University Of Tokushima Gr

• Ishimaru Naozumi

  Department Of Oral Molecular Pathology Institute Of Health Bioscience The University Of Tokushima Gr

• Hayashi Yoshio

  Department Of Chemistry Faculty Of Science Kanazawa University

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